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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus. Expand
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.
A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas. Expand
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).
Terminal repeat analysis of virus DNA from a KS lesion suggests a monoclonal expansion of KSHV in the KS tumor. Expand
Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma.
In most patients with kaposi's sarcoma and AIDS, seroconversion to positivity for antibodies against KSHV-related nuclear antigens occurs before the clinical appearance of Kaposi's Sarcoma. Expand
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA
It is demonstrated that the KSHV sequences represent a portion of a much larger DNA molecule that is located predominantly in the nucleus of the infected cells, and that their presence in the cells as large nuclear episomes supports previous sequence homology data suggesting that K SHV belongs to the herpesvirus family. Expand
Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and those without HIV infection.
The same herpesvirus-like DNA sequences are present in AIDS-associated Kaposi's sarcoma, classic Kaposi’s sarcomo, and the Kaposi' sarcoma that occurs in HIV-negative homosexual men, suggesting that all three are caused by the same infectious agent. Expand
Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae
The agent is defined as a new human herpesvirus provisionally assigned the descriptive name KS-associated herpesv virus; its formal designation is likely to be human herpes virus 8.0, the first member of this genus known to infect humans. Expand
Kaposi's sarcoma.
Four clinical variants of Kaposi's sarcoma were described that had identical histologic features but developed in specific populations and had different sites of involvement and rates of progression and these variants most likely represent different manifestations. Expand
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.
Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]) is a herpesvirus linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma, and aExpand
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.
The tightly restricted expression of K SHV proteins in vivo differs from the dysregulated expression of inducible KSHV genes in vitro and suggests that viral gene expression in KSHv-infected cell lines does not accurately reflect what occurs in diseased tissues. Expand