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Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression.
  • Fan Yang, Yu-ping Xu, +17 authors L. Liu
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 1 November 2009
Neurofibromatosis type 1 (NF1) microdeletion is a large genomic deletion that embraces at least 11 continuous genes at human chromosome 17q11.2. To date, most of these genes' functions still remainExpand
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Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
Five new lindenane disesquiterpenoids, chlorajaponilides A-E (1-5), together with 11 known analogues were isolated from whole plants of Chloranthus japonicus. The structure and absolute configurationExpand
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[Studies on the chemical constituents of Smilax glabra].
Smilax glabra is a well-known traditional Chinese medicine which has been used clinically to prevent leptospirosis, to treat syphilis, and acute bacterial dysentery, etc. Its extracts showedExpand
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Identification and Characterization of Three Novel Small Interference RNAs That Effectively Down-Regulate the Isolated Nucleocapsid Gene Expression of SARS Coronavirus
Nucleocapsid (N) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a major pathological determinant in the host that may cause host cell apoptosis, upregulate theExpand
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[Screening of HIV-1 replication inhibitors by using pseudotyped virus system].
  • Y. Cao, Y. Guo
  • Biology, Medicine
  • Yao xue xue bao = Acta pharmaceutica Sinica
  • 1 March 2008
This study is to establish a cell-based pharmacological model targeting HIV-1 replication for compounds screening and to screen compounds randomly selected from compounds library by using thisExpand
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[Establishment of pharmacological evaluation system for non-nucleoside reverse-transcriptase inhibitors resistant HIV-1].
Consistent non-nucleoside reverse-transcriptase inhibitors (NNRTIs) resistant HIV-1 strains occurred due to the clinical use for more than ten years of efavirenz (EFV), nevirapine (NVP), andExpand
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Small Interfering RNA Effectively Inhibits the Expression of SARS Coronavirus Membrane Gene at Two Novel Targeting Sites
Small interfering RNA (siRNA) is a class of duplex RNA molecules of 21-25 nt nucleotides in length functioning post-transcriptionally to downregulate targeted gene expression. The membrane (M)Expand
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Establishment and utilization of a tetracycline-controlled inducible RNA interfering system to repress gene expression in chronic myelogenous leukemia cells.
RNA interference (RNAi), a posttranscriptional gene silencing process mediated by small double-stranded RNA specifically complementary to the targeted transcript, has been used extensively in theExpand
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[Shizukaol F: a new structural type inhibitor of HIV-1 reverse transcriptase RNase H].
This study is to investigate the mechanism of action of lindenane disesquiterpenoid shizukaol F on HIV-1 replication. Real time quantity PCR, ELISA assay and fluorescence methods were used to testExpand
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Anti-HIV and NO production inhibition activities of epi-aleuritolic acid derivatives
  • Jia-Bao Liu, Ying Zhang, +5 authors S. Li
  • Chemistry, Medicine
  • Journal of Asian natural products research
  • 1 May 2013
Fifteen epi-aleuritolic acid derivatives were synthesized and evaluated for anti-HIV activity in 293 T cells and NO production inhibition activity. Of the derivatives, 1, 2, 3, 4, 11, and 13 showedExpand
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