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Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline
Cabergoline (CAB), the first-line drug for treatment of prolactinomas, is effective in suppressing prolactin hypersecretion, reducing tumor size, and restoring gonadal function. However, mechanisms… Expand
Curcumin Protects Against Intestinal Origin Endotoxemia in Rat Liver Cirrhosis by Targeting PCSK9.
Intestinal origin endotoxemia always occurs in severe liver injury. The aim of the current study was to test antiendotoxemia effect of curcumin on tetrachloride (CCl4 )-induced liver cirrhosis rats,… Expand
Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes.
In the past decade, a number of case-control studies have been carried out to investigate the relationship between the HHEX polymorphism and type 2 diabetes (T2D). However, the results have been… Expand
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.
- Y. Cai, Guanqun Huang, +7 authors Si Zhang
- Biology, Medicine
- Biochimica et biophysica acta. Molecular cell…
- 1 February 2018
We previously reported that Smad ubiquitin regulatory factor 2 (Smurf2) activity was decreased in human fibrotic livers. Here, we overexpressed Smurf2 in livers of transgenic mice and observed… Expand
MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway
Colorectal cancer (CRC) is one of the most common cancers worldwide, and microRNAs play important roles in CRC progression. This study aimed to investigate the roles of miR-146a-5p in human CRC and… Expand
MicroRNA-146a-5p attenuates liver fibrosis by suppressing profibrogenic effects of TGFβ1 and lipopolysaccharide.
- Yanting Zou, Y. Cai, D. Lu, Y. Zhou, Q. Yao, S. Zhang
- Chemistry, Medicine
- Cellular signalling
- 1 November 2017
Liver fibrosis is characterized by proliferation and activation of hepatic stellate cells (HSCs). Transforming growth factor-β1 (TGFβ1) is crucial for liver fibrogenesis, and gut-derived endotoxin… Expand
Abnormal expression of Smurf2 during the process of rat liver fibrosis.
OBJECTIVE Liver fibrosis is a prelude of liver cirrhosis. Currently the molecular mechanism of liver fibrosis is not clear. The purpose of this study is to screen the abnormally expressed genes of… Expand
Purification, characterization, and pathogenicity of urease produced by Vibrio parahaemolyticus
Vibrio parahaemolyticus is a halophilic bacterium associated with gastroenteritis and traveller's diarrhea. The urease‐positive, Kanagawa‐negative V. parahaemolyticus had been isolated from patients… Expand
Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation
This current study tested expression and potential biological functions of Gab3 in human glioma. Gab3 mRNA and protein expression was significantly elevated in human glioma tissues and glioma cells.… Expand
Clinical features and long-term surgical outcomes in 39 patients withtumor-related trigeminal neuralgia compared with 360 patients with idiopathic trigeminal neuralgia
Abstract Objective: The purpose of this study was to compare clinical features, long-term surgical outcomes between patients with idiopathic and tumor-related trigeminal neuralgia (TN), and to… Expand