Bioactive kaurane diterpenoids from Annona glabra.
- F. Chang, P. Yang, J. Lin, K. Lee, Y. C. Wu
- Chemistry, BiologyJournal of Natural Products
- 1 April 1998
Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane diterpenoids, which exhibited mild activity against HIV replication in H9 lymphocyte cells, and 16 alpha-17-dihydroxy-ent-kauran-19-oic acid showed significant inhibition of HIV-reverse transcriptase.
Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa.
- Y. C. Wu, Y. Hung, F. Chang, M. Cosentino, H. Wang, K. Lee
- ChemistryJournal of Natural Products
- 22 June 1996
Among these 14 compounds, 16 beta, 17-dihydroxy-ent-kauran-19-oic acid showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL (therapeutic index > 5).
Novel cytotoxic annonaceous acetogenins from Annona muricata.
Seven new annonaceous acetogenins, muricins A-G, as well as five known compounds, a mixture of muricatetrocin A and muricats B, showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines Hep G(2) and 2,2,15.
Two new natural azafluorene alkaloids and a cytotoxic aporphine alkaloid from Polyalthia longifolia.
- Y. C. Wu, C. Duh, S. K. Wang, K. S. Chen, T. Yang
- Chemistry, BiologyJournal of Natural Products
- 1990
The stem and stem bark of Polyalthia longifolia afforded the cytotoxic aporphine alkaloid liriodenine and three azafluorene alkaloids, darienine, polyfothine, and isooncodine, which are new natural compounds.
Cytotoxic pyridone alkaloids from the leaves of Piper aborescens.
- C. Duh, Y. C. Wu, S. K. Wang
- ChemistryJournal of Natural Products
- 1 November 1990
Bioactivity-guided fractionation of a CHCl3 extract of the leaves of Piper aborescens afforded a new cytotoxic pyridone alkaloid, N-(3-methoxy-4,5-methylenedioxydihydrocinnamoyl)-delta…
Four alkaloids from Annona cherimola.
- C. Y. Chen, F. Chang, W. Pan, Y. C. Wu
- ChemistryPhytochemistry
- 1 April 2001
Antiplatelet aggregation constituents from Annona purpurea.
Among them, 11-14 were characterized as new compounds and alkaloids, 5-8, 10, and 12-14 exhibited significant antiplatelet aggregation activity.
A novel agarofuran sesquiterpene, celahin D from Celastrus hindsii Benth.
- H. C. Huang, C. C. Shen, C. F. Chen, Y. C. Wu, Y. H. Ku
- ChemistryChemical and pharmaceutical bulletin
- 1 July 2000
A novel agarofuran sesquiterpene polyol ester, 1beta,2beta,6alpha,15beta-tetracetoxy-8 beta,9alpha-dibenzoyloxy-beta- dihydroagarofuran (celahin D) and three known triterpenes, loranthol, lupenone and friedelinol were obtained from the titled plant.
Cytotoxic constituents of Polyalthia longifolia var. pendula.
- C. Y. Chen, F. Chang, Y. C. Wu
- ChemistryJournal of Natural Products
- 8 September 2000
A new halimane diterpene, 3beta,5beta, 16alpha-trihydroxyhalima-13(14)-en-15,16-olide (1), and a new oxoprotoberberine alkaloid, (-)-8-oxopolyalthiaine (2), along with 20 known compounds, were…
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