Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activation
It is demonstrated that sauchinone inhibits LPS‐inducible iNOS, TNF‐α and COX‐2 expression in macrophages through suppression of I‐κBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP‐1 activation, which may constitute anti‐inflammatory effects of the lignan.
The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry.
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation.
- Ae-Kyung Lee, S. Sung, Y. C. Kim, Sang -Geon Kim
- Biology, ChemistryBritish Journal of Pharmacology
It is demonstrated that sauchinone inhibits LPS-inducible iNOS, TNF-alpha and COX-2 expression in macrophages through suppression of I-kappaBalpha phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may constitute anti-inflammatory effects of the lignan.
Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.
Neuroprotective limonoids of root bark of Dictamnus dasycarpus.
Compounds, 2, 3, 6, 9, 10, and 11 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM.
ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice.
Protective effect of quercetin against paraquat-induced lung injury in rats.
Iridoids from Scrophularia buergeriana attenuate glutamate‐induced neurotoxicity in rat cortical cultures
- S. Kim, Kyung Ah Koo, S. Sung, C. Ma, Jeong Seon Yoon, Y. C. Kim
- BiologyJournal of Neuroscience Research
- 15 December 2003
Results suggested that Harp and 8‐MCA‐Harp protected primary cultured neurons against glutamate‐induced oxidative stress primarily by acting on the antioxidative defense system and on glutamatergic receptors, respectively.
(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.
Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin and kobophenol A, which inhibited AChE activity in a dose-dependent manner.