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The Ctenophore Genome and the Evolutionary Origins of Neural Systems
The draft genome of Pleurobrachia bachei, Pacific sea gooseberry, together with ten other ctenophore transcriptomes, are presented, and show that they are remarkably distinct from other animal genomes in their content of neurogenic, immune and developmental genes. Expand
Ionotropic Crustacean Olfactory Receptors
It is reported that spiny lobsters, Panulirus argus, express ionotropic receptors (IRs), the insect chemosensory variants of ionotropic glutamate receptors, which are the only type of olfactory receptor that is detected in spiny lobsterOlfactory tissue, suggesting that they likely mediate Olfactory signaling. Expand
The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings.
This work uses conventional single channel inside-out and outside-out patch recording from the human TRPA1 channel transiently expressed in human embryonic kidney 293T cells to characterize the selectivity of the channel for inorganic mono-/divalent and organic monovalent cations in the presence of allylisothiocyanate (AITC). Expand
Blockade of insect odorant receptor currents by amiloride derivatives.
- Gregory M. Pask, Y. Bobkov, E. Corey, B. Ache, L. Zwiebel
- Medicine, Biology
- Chemical senses
- 1 March 2013
It is demonstrated that amiloride and several derivatives, which have been extensively used as blockers for various ion channels and transporters, also block odorant-gated currents from 2 OR complexes from the malaria vector mosquito Anopheles gambiae. Expand
Intrinsically bursting olfactory receptor neurons.
It is suggested that intrinsically bursting lobster primary olfactory receptor cells that respond to odors with a phase-dependent burst of action potentials provide a novel way for encoding odor information. Expand
Imaging ensemble activity in arthropod olfactory receptor neurons in situ.
Being able to record from many ORNs simultaneously over an extended period of time not only allows more accurate estimates of neuronal population activity but also dramatically improves the ability to identify potential new functional subpopulations of ORNs, especially those with more subtle differences in responsiveness, ligand specificity, and/or transduction mechanisms. Expand
Candidate pheromone receptors of codling moth Cydia pomonella respond to pheromones and kairomones
These findings represent important breakthroughs in the deorphanization of codling moth pheromone receptors, as well as more broadly into insect ecology and evolution and, consequently, for the development of sustainable pest control strategies based on manipulating chemosensory communication. Expand
Block by amiloride derivatives of odor-evoked discharge in lobster olfactory receptor neurons through action on a presumptive TRP channel.
It is reported that pyrazine derivatives of amiloride reversibly inhibit odorant-evoked activity in lobster olfactory receptor neurons and block a presumptive transient receptor potential (TRP) channel that is the likely downstream target of phosphoinositide signaling in these cells. Expand
Neurally Encoding Time for Olfactory Navigation
- In Jun Park, A. Hein, Y. Bobkov, Matthew A. Reidenbach, B. Ache, J. Príncipe
- Biology, Computer Science
- PLoS Comput. Biol.
- 1 January 2016
This work uses recurrence theory to show that information about position relative to the source of the odor plume is embedded in the timing between odor pulses, and suggests a mechanism for extracting and encoding temporal information from the sensory environment that could have broad utility for neural information processing. Expand
Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons.
It is shown that the Na(+)-gated channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate, SKF96365, ruthenium red, Al3+, Gd3+, and La3+. Expand