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“Megavirales”, a proposed new order for eukaryotic nucleocytoplasmic large DNA viruses
TLDR
These characteristics lead us to propose assigning an official taxonomic rank to the NCLDVs as the order “Megavirales”, in reference to the large size of the virions and genomes of these viruses. Expand
Assembly of the mariner Mos1 Synaptic Complex
TLDR
The sequence of the Mos1 inverted terminal repeats contains overlapping palindromic and mirror motifs, which could account for the binding of two transposase molecules “side by side” on the same inverted terminal repeat. Expand
Mariner Mos1 transposase dimerizes prior to ITR binding.
TLDR
Evidence that the transposase cis-dimer is the active species in inverted terminal repeat (ITR) binding is provided and it is observed that the catalytic domain of the mariner Mos1 transposases modulates efficient transpos enzyme-transposase interactions in the absence of thetransposon ends. Expand
The Human SETMAR Protein Preserves Most of the Activities of the Ancestral Hsmar1 Transposase
TLDR
The key activity for the mariner domain is therefore the robust DNA-binding and looping activity which has a high potential for targeting the histone methylase domain to the many thousands of specific binding sites in the human genome provided by copies of the Hsmar1 transposon. Expand
The wild-type conformation of the Mos-1 Inverted Terminal Repeats is suboptimal for transposition in bacteria
TLDR
The two inverted terminal repeats (ITRs) flanking the Mos-1 mariner element differ in sequence at four positions and it is shown that the transposase binds to the 3′ I TR better than to the 5′ ITR. Expand
Genomic Sequence of Spodoptera frugiperda Ascovirus 1a, an Enveloped, Double-Stranded DNA Insect Virus That Manipulates Apoptosis for Viral Reproduction
TLDR
The SfAV-1a genome sequence will facilitate the determination of how ascoviruses manipulate apoptosis to generate the novel virion-containing vesicles characteristic of these viruses and enable study of their origin and evolution. Expand
A survey of transposable element classification systems--a call for a fundamental update to meet the challenge of their diversity and complexity.
TLDR
The outline of a universal TE classification is proposed, a set of methods and classification rules that could be used by all scientific communities involved in the study of TEs are proposed, and a 5-year schedule for the establishment of an International Committee for Taxonomy of Transposable Elements (ICTTE) is proposed. Expand
Particle and genomic characteristics of a new member of the Ascoviridae: Diadromus pulchellus ascovirus.
TLDR
The structural and genomic features of DpAV suggest that this virus belongs to an ascovirus sub-family different from that containing the ascoviruses previously found to infect species of Noctuidae (Federici et al., 1991). Expand
Conservation of Palindromic and Mirror Motifs within Inverted Terminal Repeats of mariner-like Elements.
TLDR
The findings show that in all the MLE ITRs, the outer half was better conserved than the inner half, and the properties of the mirror motifs were shown to be responsible for the bend in each ITR that helps to stabilize transposase-ITR interactions. Expand
Biological and molecular features of the relationships between Diadromus pulchellus ascovirus, a parasitoid hymenopteran wasp (Diadromus pulchellus) and its lepidopteran host, Acrolepiopsis
TLDR
The presence of the DpAV genome in all Diadromus somatic cells suggests that it is inherited by vertical transmission and its relationship with the parasitoid wasp D. pulchellus during its development are compared to those of the ichnoviruses. Expand
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