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Phosphorylation-dependent regulation of septin dynamics during the cell cycle.
Septins are GTPases involved in cytokinesis. In yeast, they form a ring at the cleavage site. Using FRAP, we show that septins are mobile within the ring at bud emergence and telophase and areExpand
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Asymmetric Loading of Kar9 onto Spindle Poles and Microtubules Ensures Proper Spindle Alignment
Spindle alignment is the process in which the two spindle poles are directed toward preselected and opposite cell ends. In budding yeast, the APC-related molecule Kar9 is required for properExpand
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The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage
During anaphase, spindle elongation pulls sister chromatids apart until each pair is fully separated. In turn, cytokinesis cleaves the cell between the separated chromosomes. What ensures thatExpand
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The septin family of GTPases: architecture and dynamics
Septins comprise a conserved family of proteins that are found primarily in fungi and animals. These GTP-binding proteins have several roles during cell division, cytoskeletal organization andExpand
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Spatial Coordination of Cytokinetic Events by Compartmentalization of the Cell Cortex
During cytokinesis, furrow ingression and plasma membrane fission irreversibly separate daughter cells. How actomyosin ring assembly and contraction, vesicle fusion, and abscission are spatiallyExpand
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Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae.
A Saccharomyces cerevisiae mutant unable to grow in a cdc28-1N background was isolated and shown to be affected in the ELM1 gene. Elm1 is a protein kinase, thought to be a negative regulator ofExpand
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A Role for Codon Order in Translation Dynamics
The genetic code is degenerate. Each amino acid is encoded by up to six synonymous codons; the choice between these codons influences gene expression. Here, we show that in coding sequences, once aExpand
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Polarized Growth Controls Cell Shape and Bipolar Bud Site Selection in Saccharomyces cerevisiae
ABSTRACT We examined the relationship between polarized growth and division site selection, two fundamental processes important for proper development of eukaryotes. Diploid SaccharomycesExpand
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Spindle orientation in Saccharomyces cerevisiae depends on the transport of microtubule ends along polarized actin cables
Microtubules and actin filaments interact and cooperate in many processes in eukaryotic cells, but the functional implications of such interactions are not well understood. In the yeast SaccharomycesExpand
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A mechanism for asymmetric segregation of age during yeast budding
Ageing and the mortality that ensues are sustainable for the species only if age is reset in newborns. In budding yeast, buds are made young whereas ageing factors, such as carbonylated proteins andExpand
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