• Publications
  • Influence
BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment.
Breast cancer initiating cells (BCICs), which can fully recapitulate the tumor origin and are often resistant to chemo- and radiotherapy, are currently considered as a major obstacle for breastExpand
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Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer
Significance Colorectal cancer patients often relapse due to resistance to chemotherapy. The tumor microenvironment is known to contribute to tumor aggressiveness and chemoresistance, but theExpand
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Downregulation of zinc-α2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-α in adipocytes
Zinc-α2-glycoprotein (ZAG, also listed as AZGP1 in the MGI Database), a lipid-mobilising factor, has recently been suggested as a potential candidate in the modulation of body weight. We investigatedExpand
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RASAL2 activates RAC1 to promote triple-negative breast cancer progression.
Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for recurrence in these individuals remains poorly understood.Expand
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Mitochondria Regulate Neutrophil Activation by Generating ATP for Autocrine Purinergic Signaling*
Background: Purinergic signaling regulates neutrophil activation. The source of ATP required for this process is unknown. Results: Mitochondria form the ATP that initiates purinergic signaling, andExpand
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Expression and Relevance of TRPS-1: A New GATA Transcription Factor in Breast Cancer
GATA transcription factor family members have been found to play a critical role in the differentiation of many tissue types. For example, GATA-3 has been found to be highly correlated with estrogenExpand
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Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling*
Background: Autocrine purinergic signaling regulates T cell function. Results: We found that mitochondria are the source of ATP that drives these signaling mechanisms. Conclusion: Mitochondria areExpand
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Identification of two antagonists of the scavenger receptor CD36 using a high-throughput screening model.
CD36, a class B scavenger receptor, is an integral membrane protein that mediates the endocytosis of modified lipoproteins. The functions of CD36 are complex and have been associated withExpand
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KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer
PTEN deficiency in breast cancer leads to resistance to PI3K–AKT inhibitor treatment despite aberrant activation of this signaling pathway. Here, we report that genetic depletion or small moleculeExpand
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A study of UbcH10 expression and its association with recurrence of meningiomas
UbcH10 is an important regulator for the mitotic spindle assembly checkpoint pathway that regulates cell‐cycle progression. Overexpression of UbcH10 significantly correlated with advanced tumor gradeExpand
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