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Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.
The nucleolar protein PinX1 has been proposed to be a putative tumor suppressor due to its binding to and inhibition of the catalytic activity of telomerase, an enzyme that is highly expressed inExpand
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Strange Particle Production in $p+p$ Collisions at $\sqrt{s}$= 200GeV
We present strange particle spectra and yields measured atmid-rapidity in sqrt text s=200 GeV proton-proton (p+p) collisions atRHIC. We find that the previously observed universal transverseExpand
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Incident Energy Dependence of pt Correlations at RHIC
We present results for two-particle transverse momentum correlations, ({Delta}p{sub t,i}{Delta}p{sub t,j}), as a function of event centrality for Au+Au collisions at {radical}s{sub NN} = 20, 62, 130,Expand
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Evaluation of the air bronchogram sign on CT in solitary pulmonary lesions.
PURPOSE Our goal was to evaluate the presence and the significance of the air bronchogram sign in solitary pulmonary lesions (SPL) on CT. METHOD One hundred thirty-two patients with SPL whoExpand
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Effect of Konjac food on blood glucose level in patients with diabetes.
Seventy-two type II diabetic subjects were given Konjac food for 65 days. The data analyzed by multiple F test indicate that the fasting blood glucose (FBG) and the 2-h postprandial blood glucoseExpand
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Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.
The factor PinX1 has been shown as a telomerase inhibitor evolutionarily conserved in both the yeast and the human being. yPinX1 inhibits telomerase activity by sequestering yTERT (telomerase reverseExpand
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Nucleolar localization of TERT is unrelated to telomerase function in human cells
Telomerase maintains telomere length and has been implicated in both aging and carcinogenesis of human cells. This enzyme is a specialized ribonucleoprotein (RNP) complex, minimally consisting of twoExpand
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Ectopic expression of a COOH-terminal fragment of the human telomerase reverse transcriptase leads to telomere dysfunction and reduction of growth and tumorigenicity in HeLa cells.
The COOH-terminus of telomerase reverse transcriptase (hTERT) has been shown to participatein the nuclear translocation of TERT. Here, we constructed plasmids expressing the COOH-terminal M(r) 27,000Expand
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A human TERT C-terminal polypeptide sensitizes HeLa cells to H2O2-induced senescence without affecting telomerase enzymatic activity.
We have constructed a 27-kDa hTERT C-terminal polypeptide (hTERTC27) devoid of domains required for telomerase activity and demonstrated that it is capable of nuclear translocation/telomere-endExpand
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Homotransplantation of testis. A report of 11 cases
Testis homotransplantation has been carried out in 11 patients since 1986. Of them, 8 suffered from congenital testicular dysplasia and the other 3 from orchiatrophy as a result of orchitis.Expand
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