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The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.
OBJECTIVE To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios. DESIGN Prospective cohort studyExpand
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Prehospital Transfusion of Plasma and Red Blood Cells in Trauma Patients
Abstract Objective. Earlier use of plasma and red blood cells (RBCs) has been associated with improved survival in trauma patients with substantial hemorrhage. We hypothesized that prehospitalExpand
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C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice
The expansion of a hexanucleotide (GGGGCC) repeat in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both the function of C9ORF72 and theExpand
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A Neonatal Fc Receptor-Targeted Mucosal Vaccine Strategy Effectively Induces HIV-1 Antigen-Specific Immunity to Genital Infection
ABSTRACT Strategies to prevent the sexual transmission of HIV include vaccines that elicit durable, protective mucosal immune responses. A key to effective mucosal immunity is the capacity forExpand
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Severe Acute Pancreatitis in China: Etiology and Mortality on 1976 Patients
Objectives: Many epidemiological studies have recently been published on acute pancreatitis; however, there is no known published report on pancreatitis in China. The present study aims to assess theExpand
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Cluster-Based Consensus Time Synchronization for Wireless Sensor Networks
This paper proposes a new time synchronization algorithm for wireless sensor networks, named clustered consensus time synchronization (CCTS) and improves the convergence rate due to the combination of clustering topologies. Expand
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Prophylactic Antibiotics Cannot Reduce Infected Pancreatic Necrosis and Mortality in Acute Necrotizing Pancreatitis: Evidence From a Meta-Analysis of Randomized Controlled Trials
BACKGROUND:There is no agreement whether intravenous prophylactic antibiotics can reduce infected pancreatic necrosis and mortality in acute necrotizing pancreatitis (ANP). We performed aExpand
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Analytical methods in lipidomics and their applications.
■ CONTENTS Analytical Methods of Lipidomics 162 Extraction Methods of Lipids 163 Direct-Infusion MS-Based Lipidomics Analysis 163 Electrospray Ionization (ESI) MS 163 Matrix-Assisted Laser DesorptionExpand
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Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development
Methylation of cytosine is a DNA modification associated with gene repression. Recently, a novel cytosine modification, 5-hydroxymethylcytosine (5-hmC) has been discovered. Here we examine 5-hmCExpand
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