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Quality of life for children with fecal incontinence after surgically corrected anorectal malformation.
PURPOSE The aim of this study was to investigate influences of fecal incontinence on children's quality of life after surgically corrected anorectal malformation. METHODS Seventy-one children withExpand
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Normal and abnormal embryonic development of the anorectum in rats.
BACKGROUND The embryologic and pathologic aspect of anorectal malformation (ARM) remains poorly understood. There is no universally accepted theory to explain anorectal embryology and the abnormalExpand
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Wnt5a expression in the hindgut of fetal rats with chemically induced anorectal malformations—studies in the ETU rat model
PurposeWnt5a is involved in the initiating and patterning morphological adaptations of gut. However, its role remained unknown during terminal hindgut development in the normal and anorectalExpand
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Long-term outcome and quality of life after the Swenson procedure for Hirschsprung's disease.
BACKGROUND/PURPOSE The aim of this study was to investigate long-term outcome and quality of life after the Swenson operation for rectosigmoid Hirschsprung's Disease (HD). METHODS Forty-fiveExpand
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Quantitative analysis of sacral parasympathetic nucleus innervating the rectum in rats with anorectal malformation.
BACKGROUND/PURPOSE The purpose of this experiment was to identify the neurons in the lumbosacral spinal cord involved in colon-rectal function and to compare normal and anorectal malformation ofExpand
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Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations
Fecal incontinence and constipation still remain the major complications after procedures for anorectal malformations (ARMs). Previous studies have demonstrated a decrease of neural cell inExpand
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Reduced Wnt3a expression correlates with poor development of the hindgut in rats with anorectal malformations.
Embryogenesis is orchestrated by the wingless-type MMTV integration site family (WNT) signaling pathways, including Wnt3a. This study was performed to investigate the expression of Wnt3a in theExpand
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LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children
Hepatoblastoma is one of the malignant liver tumors in children. However, genetic mechanisms underpinning the initiation of hepatoblastoma remain largely unclear. The previous study showed thatExpand
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Hedgehog gene polymorphisms are associated with the risk of Hirschsprung's disease and anorectal malformation in a Chinese population.
Hedgehog (HH) is one of the key morphogens expressed in the gut mesenchyme that control animal development and tissue homeostasis. The HH gene has been shown to be closely associated withExpand
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The Expression of Shh, Ptch1, and Gli1 in the Developing Caudal Spinal Cord of Fetal Rats With Anorectal Malformations.
BACKGROUND Postoperative incontinence and constipation still remain the major complications of anorectal malformations (ARMs), despite improvements in their treatment. One of the most importantExpand
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