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A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans.
This work characterized a fungal "two-component" system that controls these fundamental cellular functions via the Pbs2-Hog1 MAPK cascade and highlights unique adaptations of this global two-component MAPK signaling cascade in a ubiquitous human fungal pathogen. Expand
Carbonic Anhydrase and CO2 Sensing during Cryptococcus neoformans Growth, Differentiation, and Virulence
Diverse roles of an ancient enzyme class in enabling environmental survival of a ubiquitous human pathogen are illustrated, indicating a major role for carbonic anhydrase and CO2/HCO3- in this developmental cascade leading to the production of infectious spores. Expand
Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.
Topics focused on in this article include species description, pathogenesis, life cycle, capsule, and stress response, which serve to highlight the specializations in virulence that have occurred in this unique encapsulated melanin-forming yeast that causes global deaths estimated at more than 600,000 annually. Expand
Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans.
It is reported that the structurally conserved Pbs2-Hog1 MAP kinase cascade has been specifically recruited as a global regulator to control morphological differentiation and virulence factors in the highly virulence serotype A H99 clinical isolate, but not in the laboratory-generated and less virulent serotype D strain JEC21. Expand
Master and Commander in Fungal Pathogens: the Two-Component System and the HOG Signaling Pathway
  • Y. Bahn
  • Biology, Medicine
  • Eukaryotic Cell
  • 24 October 2008
These features confer an underlying distinction between pathogenic and nonpathogenic microbes, along with regulation of diverse virulence factors, that are required for survival at different host anatomical sites having distinct environmental conditions, during dissemination of organisms, or to counterbalance changes in overall host physiological conditions. Expand
Unique Evolution of the UPR Pathway with a Novel bZIP Transcription Factor, Hxl1, for Controlling Pathogenicity of Cryptococcus neoformans
Irene1 and Hxl1 were shown to be critical for virulence of C. neoformans, suggesting UPR signaling as a novel antifungal therapeutic target. Expand
Deciphering the Model Pathogenic Fungus Cryptococcus Neoformans
The biology of C. neoformans is discussed in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host. Expand
Sensing the environment: lessons from fungi
Recent progress is reviewed in understanding of how fungal-signalling circuits operate at the molecular level to sense and respond to a plethora of environmental cues. Expand
Remodeling of Global Transcription Patterns of Cryptococcus neoformans Genes Mediated by the Stress-Activated HOG Signaling Pathways
Novel stress defense and HOG-dependent genes, which encode a sodium/potassium efflux pump, protein kinase, multidrug transporter system, and elements of the ubiquitin-dependent system are discovered. Expand
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.
Activation of the cAMP-PKA pathway by glucose and amino acids represents a nutrient coincidence detection system shared in other pathogenic fungi. Expand