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A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling
A signaling pathway triggers cell proliferation in response to increased stiffness in the external environment. Cell Proliferation in Hard Environments The extracellular matrix that surrounds cellsExpand
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Loss of profilin‐1 expression enhances breast cancer cell motility by Ena/VASP proteins
We previously showed that silencing profilin‐1 (Pfn1) expression increases breast cancer cell motility, but the underlying mechanisms have not been explored. Herein, we demonstrate that loss of Pfn1Expand
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Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells
Profilin1, a ubiquitously expressed actin-binding protein, plays a critical role in cell migration through actin cytoskeletal regulation. Given the traditional view of profilin1 as a promigratoryExpand
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Molecular insights on context-specific role of profilin-1 in cell migration
Profilin-1 (Pfn1) is a ubiquitously expressed actin-monomer binding protein that has been linked to many cellular activities ranging from control of actin polymerization to gene transcription.Expand
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Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening.
Arterial stiffening is a risk factor for cardiovascular disease, but how arteries stay supple is unknown. Here, we show that apolipoprotein E (apoE) and apoE-containing high-density lipoproteinExpand
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N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells
SUMMARY In contrast to the accepted pro-proliferative effect of cell-matrix adhesion, the proliferative effect of cadherin-mediated cell-cell adhesion remains unresolved. Here, we studied the effectExpand
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m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate*
m-calpain plays a critical role in cell migration enabling rear de-adhesion of adherent cells by cleaving structural components of the adhesion plaques. Growth factors and chemokines regulateExpand
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Profilin‐1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells
Profilin‐1 (Pfn1), a ubiquitously expressed actin‐binding protein, has been regarded as a tumor‐suppressor molecule for breast cancer. Since AKT signaling impacts cell survival and proliferation, inExpand
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Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening
Arterial stiffening is a hallmark of aging and risk factor for cardiovascular disease, yet its regulation is poorly understood. Here we use mouse modeling to show that matrix metalloproteinase-12Expand
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Minute changes in composition of polymer substrates produce amplified differences in cell adhesion and motility via optimal ligand conditioning.
We explored the interplay between substratum chemistry of polymeric materials and surface-adsorbed ligand concentration (human plasma fibronectin) in the control of cell adhesion and cell motility.Expand
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