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Decreased membrane fluidity and unsaturated fatty acids in Niemann-Pick disease type C fibroblasts.
The results suggest that a NP-C mutation causes complex alterations in cellular lipid contents and biophysical properties of the membrane.
Studies on bile acids in bear bile.
Role of endogenous and exogenous cholesterol in liver as the precursor for bile acids in rats
The results showed that endogenous cholesterol synthesized newly from [1-14C] acetate in the liver was incorporated into both cholic acid and chenodeoxycholic acid in a similar way, while exogenous lipoprotein-[1,2-3H) cholesterol delivered to hepatocytes from hepatic circulation was incorporate into chenodesoxycholics acid at a higher rate.
Cholic acid synthesis from 26-hydroxycholesterol and 3-hydroxy-5-cholestenoic acid in the rabbit.
Initial 26-hydroxycholesterol followed by 7-alpha-hydroxylation can provide sufficient amounts of cholic acid to be considered a quantitatively significant pathway for bile acid synthesis, and in addition it is the only pathway that can be the source of the circulating levels of C24 and C27 monohydroxy bile acids.
Formation of bile acids in hemoglobin-free perfused rat livers.
Identification of 3 , 7 -dihydroxychol-5-enoic acid in fistula bile of the rat given cholesterol-4- 14 C and DL-mevalonate-2- 14 C.
Effect of diabetes on the metabolism of chenodeoxycholic acid in isolated perfused rat liver.
The results indicate that not only 6 beta-hydroxylation of chenodeoxycholic acid to alpha-muricholic acid but also 7-epimerization of the latter acid to beta-muricolic acid is suppressed in an insulin-deficient state in rats.
Effect of chitosan feeding on intestinal bile acid metabolism in rats
The data suggest that chitosan feeding affects the metabolism of intestinal bile acids in rats and reduces the concentration of α-,β-, and ω-muricholic acids, and lithocholic acid.
Isolation of 3 7 -dihydroxychol-5-en-24-oic acid, an intermediate of chenodeoxycholic acid biogenesis, from fistula bile of the rat and hen.
Further studies on the possible compartmentation of the precursor pool of cholesterol for the biosynthesis of cholic acid in the rat.
Data indicate that hepatic microsomal free cholesterol which was newly synthesized in situ was preferentially incorporated into cholic acid.