Novel selective ligands for free fatty acid receptors GPR120 and GPR40
- Takafumi Hara, A. Hirasawa, G. Tsujimoto
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 27 May 2009
These studies identified a selective GPR40 agonist and several GPR120 partial agonists, and similar profiles of glucagon-like peptide-1 secretion were seen for mouse enteroendocrine cell line, STC-1 cells, which express GPR 120 endogenously.
Chemical Constituents of the Bryophytes
- Y. Asakawa
- Environmental Science, Biology
- 1995
In the twelve years since the first review article dealing with chemical constituents of the Hepaticae appeared in this series as Volume 42 (19), several short reviews concerned with chemical…
Biologically active compounds from bryophytes
- Y. Asakawa
- Chemistry
- 1 January 2007
Abstract Liverworts produce a great variety of lipophilic terpenoids, aromatic compounds, and acetogenins. Many of these constituents have characteristic scents, pungency, and bitterness, and display…
Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.
- Kanako Iwasaki, N. Harada, N. Inagaki
- BiologyEndocrinology
- 1 March 2015
GPR120 is expressed abundantly in K cells of the upper small intestine and plays a critical role in lipid-induced GIP secretion.
Phytochemical and biological studies of bryophytes.
- Y. Asakawa, A. Ludwiczuk, F. Nagashima
- BiologyPhytochemistry
- 1 July 2013
CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.
- M. H. Ozdener, Selvakumar Subramaniam, N. Khan
- Biology, MedicineGastroenterology
- 1 April 2014
CD36 and GPR120 have nonoverlapping roles in TBC signaling during orogustatory perception of dietary lipids; these are differentially regulated by obesity.
De Novo Sequencing and Transcriptome Analysis of the Central Nervous System of Mollusc Lymnaea stagnalis by Deep RNA Sequencing
- H. Sadamoto, Hironobu Takahashi, Taketo Okada, H. Kenmoku, M. Toyota, Y. Asakawa
- BiologyPLoS ONE
- 1 August 2012
The results demonstrated that about 20,000 sequences had significant similarity to the reported sequences using a cutoff value of 1e-6, and showed the lack of molluscan sequences in the public databases, and allowed us to identify a large number of new transcripts in Lymnaea and mollUScan species.
Terpenoids biotransformation in mammals III: Biotransformation of alpha-pinene, beta-pinene, pinane, 3-carene, carane, myrcene, and p-cymene in rabbits.
- T. Ishida, Y. Asakawa, T. Takemoto, T. Aratani
- ChemistryJournal of Pharmacy and Science
- 1981
These metabolisms include allylic oxidation, epoxidation, stereoselective gem-dimethyl hydroxylation and its oxidation, cleavage of a conjugated double bond by ep oxidation, and regioselectives oxidation, some of which are not found usually in chemical reactions, and due to which various new compounds were determined.
Chemical Constituents of Hepaticae
- Y. Asakawa
- Biology, Chemistry
- 1982
It is the major object of this review to present the presently known naturally occurring terpenoids and aromatic compounds of the Hepaticae. Furthermore, the biological activity of the isolated…
Momordica charantia constituents and antidiabetic screening of the isolated major compounds.
- L. Harinantenaina, Michiyo Tanaka, Y. Asakawa
- ChemistryChemical and pharmaceutical bulletin
- 1 July 2006
This finding is the first demonstration that major pure cucurbutanoid compounds of M. charantia have in vivo hypoglycaemic effects.
...
...