Y. Araki

Publications187
h-index40
Citations6,330
Highly Influential Citations245
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Increased expression of interleukin 17 in inflammatory bowel disease
Background and aim: Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of… Expand
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Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.
BACKGROUND & AIMS Interleukin (IL)-22, a member of the IL-10 subfamily, is a recently identified T-cell-derived cytokine. We investigated IL-22 expression in the inflamed mucosa of patients with… Expand
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Ethanol‐induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway
Cell death in yeast (Saccharomyces cerevisiae) involves several apoptotic processes. Here, we report the first evidence of the following processes, which are also characteristic of apoptosis, in… Expand
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Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the Caco-2 cell line.
The barrier functions in epithelial and endothelial cells seem to be very important for maintaining normal biological homeostasis. However, it is unclear whether or how bile acids affect the… Expand
  • 79
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In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis.
Pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS)… Expand
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Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability
Background: MCM10 is essential for the initiation of chromosomal DNA replication in Saccharomyces cerevisiae. Mcm10p functionally interacts with components of the pre‐replicative complex (Mcm2‐Mcm7… Expand
  • 43
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Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.
We evaluated the effects of rat anti-mouse IL-17 neutralizing monoclonal antibody (mAb) on the development of dextran sulfate sodium (DSS)-induced colitis. Tissue samples were evaluated by standard… Expand
  • 318
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Phosphorylation of Ser-446 Determines Stability of MKP-7*
MAPK cascades can be negatively regulated by members of the MAPK phosphatase (MKP) family. However, how MKP activity is regulated is not well characterized. MKP-7, a JNK-specific phosphatase,… Expand
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Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts.
BACKGROUND & AIMS We have previously isolated and characterized human pancreatic periacinar myofibroblasts. In this study, to define the role of these cells in the pathogenesis of acute pancreatitis,… Expand
  • 164
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Curcumin Prevents the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis
Curcumin is a phenolic natural product isolated from the rhizome of Curcuma longa (turmeric). We evaluated the effects of curcumin on the development of dextran sulfate sodium (DSS)-induced… Expand
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