Chaperone release and unfolding of substrates in type III secretion
It is shown that InvC, an ATPase associated with a Salmonella enterica type III secretion system, has a critical function in substrate recognition and induces chaperone release from and unfolding of the cognate secreted protein in an ATP-dependent manner.
Genetic Analysis of the Salmonella enterica Type III Secretion-Associated ATPase InvC Defines Discrete Functional Domains
A genetic and functional analysis of InvC, the ATPase associated with the Salmonella enterica type III secretion system encoded within its pathogenicity island 1, has identified amino acid residues that are essential for specific activities ofInvC, such as nucleotide hydrolysis and membrane binding.
Bile Acid-Induced Virulence Gene Expression of Vibrio parahaemolyticus Reveals a Novel Therapeutic Potential for Bile Acid Sequestrants
An insight is provided into how bacteria, through the ingenious action of Vp-PAI genes, can take advantage of an otherwise hostile host environment and reveal a new therapeutic potential for widely used bile acid sequestrants in enteric bacterial infections.
Transcription of Vibrio parahaemolyticus T3SS1 genes is regulated by a dual regulation system consisting of the ExsACDE regulatory cascade and H-NS.
- T. Kodama, C. Yamazaki, Kwon-Sam Park, Y. Akeda, T. Iida, T. Honda
- BiologyFEMS Microbiology Letters
- 1 October 2010
Findings indicate that the transcription of V. parahaemolyticus T3SS1 genes is regulated by a dual regulatory system consisting of the ExsACDE regulatory cascade and H-NS.
VopV, an F-actin-binding type III secretion effector, is required for Vibrio parahaemolyticus-induced enterotoxicity.
Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients
Investigation of relationships of the presence of NETs and Cit-H3 with the existence of bacteria in tracheal aspirate, SIRS, diagnosis, WBC count, and concentrations of IL-8, TNF-α, cf-DNA, lactate, and HMGB1 found no significant relationships.
A large outbreak of foodborne infection attributed to Providencia alcalifaciens.
This study strongly suggests that a large outbreak of foodborne infection occurred in Fukui, Japan in November 1996 and was caused by P. alcalifaciens, a member of the family Enterobacteriaceae, and provides definitive evidence that the organism is a causative agent of gastroenteritis.
Two Regulators of Vibrio parahaemolyticus Play Important Roles in Enterotoxicity by Controlling the Expression of Genes in the Vp-PAI Region
It is reported that two novel ToxR-like transcriptional regulatory proteins (VtrA and VtrB) regulate the expression of the genes encoded within the Vp-PAI region, including those for TDH and T3SS2-related proteins.
Gene Cluster for Assembly of Pilus Colonization Factor Antigen III of Enterotoxigenic Escherichia coli
This is the first report of a complete nucleotide sequence of the type IV pili found in human ETEC, and the results provide a useful model for studying the molecular mechanism of C FA/III biogenesis and the role of CFA/III in ETEC infection.
Platelet apoptosis and apoptotic platelet clearance by macrophages in secondary dengue virus infections.
The data suggest an increased phagocytosis of DV-induced apoptotic platelets by macrophages via a phosphatidylserine-recognizing pathway in secondary DV infection.