Y. Akeda

Publications167
h-index30
Citations2,858
Highly Influential Citations170
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Chaperone release and unfolding of substrates in type III secretion
TLDR
It is shown that InvC, an ATPase associated with a Salmonella enterica type III secretion system, has a critical function in substrate recognition and induces chaperone release from and unfolding of the cognate secreted protein in an ATP-dependent manner. Expand
Bile Acid-Induced Virulence Gene Expression of Vibrio parahaemolyticus Reveals a Novel Therapeutic Potential for Bile Acid Sequestrants
TLDR
An insight is provided into how bacteria, through the ingenious action of Vp-PAI genes, can take advantage of an otherwise hostile host environment and reveal a new therapeutic potential for widely used bile acid sequestrants in enteric bacterial infections. Expand
Genetic analysis of the Salmonella enterica type III secretion-associated ATPase InvC defines discrete functional domains.
TLDR
A genetic and functional analysis of InvC, the ATPase associated with the Salmonella enterica type III secretion system encoded within its pathogenicity island 1, has identified amino acid residues that are essential for specific activities ofInvC, such as nucleotide hydrolysis and membrane binding. Expand
A large outbreak of foodborne infection attributed to Providencia alcalifaciens.
TLDR
This study strongly suggests that a large outbreak of foodborne infection occurred in Fukui, Japan in November 1996 and was caused by P. alcalifaciens, a member of the family Enterobacteriaceae, and provides definitive evidence that the organism is a causative agent of gastroenteritis. Expand
Gene Cluster for Assembly of Pilus Colonization Factor Antigen III of Enterotoxigenic Escherichia coli
TLDR
This is the first report of a complete nucleotide sequence of the type IV pili found in human ETEC, and the results provide a useful model for studying the molecular mechanism of C FA/III biogenesis and the role of CFA/III in ETEC infection. Expand
VopV, an F-actin-binding type III secretion effector, is required for Vibrio parahaemolyticus-induced enterotoxicity.
TLDR
Results indicate that the F-actin-targeting effector VopV is involved in enterotoxic activity of T3SS2-possessing bacterial pathogens. Expand
The contribution of suilysin to the pathogenesis of Streptococcus suis meningitis.
TLDR
The role of suilysin, a member of cholesterol-dependent cytolysins, in differential pathogenicity between ST1 and ST104 strains is investigated and it is suggested that it contributed to the higher bacterial density and enhanced inflammation in brain and increased mortality of meningitis in humans. Expand
Two Regulators of Vibrio parahaemolyticus Play Important Roles in Enterotoxicity by Controlling the Expression of Genes in the Vp-PAI Region
TLDR
It is reported that two novel ToxR-like transcriptional regulatory proteins (VtrA and VtrB) regulate the expression of the genes encoded within the Vp-PAI region, including those for TDH and T3SS2-related proteins. Expand
Population-Based Study of Streptococcus suis Infection in Humans in Phayao Province in Northern Thailand
TLDR
The authors' data suggest a high incidence rate of S. suis infection in the general population in Phayao Province in 2010 and confirm a cluster of three cases in 31 human cases and food safety control should be strengthened especially for raw pork products in northern Thailand. Expand
Transcription of Vibrio parahaemolyticus T3SS1 genes is regulated by a dual regulation system consisting of the ExsACDE regulatory cascade and H-NS.
TLDR
Findings indicate that the transcription of V. parahaemolyticus T3SS1 genes is regulated by a dual regulatory system consisting of the ExsACDE regulatory cascade and H-NS. Expand
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