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Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review
BackgroundNovel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we… Expand
Insulinoma-associated protein 1 (INSM1) is a useful marker for pancreatic neuroendocrine tumor
- M. Tanigawa, M. Nakayama, +18 authors H. Yano
- Biology, Medicine
- Medical Molecular Morphology
- 1 March 2018
Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA),… Expand
Prognostic Value of Programmed Death Ligand 1 and Programmed Death 1 Expression in Thymic Carcinoma
Purpose: The immune checkpoint of the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is believed to play an important role in evasion of host antitumor immune surveillance in… Expand
High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases.
Genetic testing is needed for the treatment of colorectal cancer (CRC), especially molecular-targeted therapy. The effects of anti-EGFR therapy and prognosis are affected by the presence of KRAS… Expand
Optimum fractionation for high-dose-rate endoesophageal brachytherapy following external irradiation of early stage esophageal cancer.
- Y. Akagi, Y. Hirokawa, +6 authors K. Ito
- International journal of radiation oncology…
- 1 February 1999
PURPOSE To establish the optimum fractionation for high-dose-rate (HDR) endoesophageal brachytherapy (EBT) for early stage esophageal cancer from retrospective data of patients treated with different… Expand
Optimal colorectal cancer staging criteria in TNM classification.
- H. Ueno, H. Mochizuki, +17 authors K. Sugihara
- Journal of clinical oncology : official journal…
- 1 May 2012
PURPOSE Histologic components of the TNM classification system have been repeatedly revised since the fifth edition (TNM5). TNM classification revisions provide different criteria for categorizing… Expand
Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer.
- Ichitarou Shiratsuchi, Y. Akagi, +7 authors K. Shirouzu
- Biology, Medicine
- Anticancer research
- 1 July 2011
BACKGROUND Expression of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) has been shown to increase in colorectal cancer. We examined the correlation between expression of IGF-1 and… Expand
Intersphincteric resection for very low rectal cancer: a systematic review
Radical surgical treatment for very low rectal cancer near the anus has generally involved abdominoperineal resection. Various sphincter-saving operations have been developed for such tumors to… Expand
Increased claudin-1 protein expression contributes to tumorigenesis in ulcerative colitis-associated colorectal cancer.
BACKGROUND The molecular and morphological alterations of the tight junctions in ulcerative colitis (UC)-associated colorectal cancer are still poorly understood. The possible involvement of… Expand
Transcriptional activation of a hybrid promoter composed of cytomegalovirus enhancer and beta-actin/beta-globin gene in glomerular epithelial cells in vivo.
The aim of this study was to seek a promoter, transactivated selectively in renal cells in vivo by using transgenic (tg) mouse technology. We generated two kinds of tg mouse lines carrying a green… Expand