Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines
- R. R. Mahmmoud, Sunetra Sase, G. Lubec
- Biology, PsychologyPLoS ONE
- 15 October 2015
Correlations between WME and latency in the RAM and spine density revealed a link between spine numbers and performance inThe RAM, and the study shows that spine numbers are significantly increased in the trained group, an observation that may suggest the use of this method representing a morphological parameter for memory formation studies in theRAM.
A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes
- Ajinkya S. Sase, Y. Aher, G. Lubec
- Biology, PsychologyNeuropharmacology
- 1 March 2016
Frontal cortex and hippocampus neurotransmitter receptor complex level parallels spatial memory performance in the radial arm maze
- B. Shanmugasundaram, Ajinkya S. Sase, G. Lubec
- Biology, PsychologyBehavioural Brain Research
- 1 August 2015
Individual Differences in Male Rats in a Behavioral Test Battery: A Multivariate Statistical Approach
- D. D. Feyissa, Y. Aher, E. Engidawork, H. Höger, G. Lubec, V. Korz
- Psychology, BiologyFrontiers in Behavioral Neuroscience
- 17 February 2017
A multivariate approach (principal component analysis) was applied to analyse the behavioral data of 162 male adult Sprague-Dawley rats that underwent a behavioral test battery including commonly used tests for spatial learning and memory and different behavioral patterns as well as for motor abilities.
3D-QSAR studies of substituted 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas as CCR5 receptor antagonists
- Y. Aher, Avantika Agrawal, P. Bharatam, P. Garg
- ChemistryJournal of Molecular Modeling
- 16 February 2007
Some key features in the series that are responsible for CCR5 antagonistic activity may be used to design more potent 1-(3,3-diphenylpropyl)-piperidinyl derivatives and predict their activity prior to synthesis.
The effect of modafinil on the rat dopamine transporter and dopamine receptors D1–D3 paralleling cognitive enhancement in the radial arm maze
- Yasemin Karabacak, Sunetra Sase, G. Lubec
- Biology, PsychologyFrontiers in Behavioral Neuroscience
- 19 August 2015
Modafinil was shown to enhance spatial WM in the rat in a well-documented paradigm at all the three doses and dopamine reuptake inhibition with subsequent modulation of D1–3-CC is proposed as a possible mechanism of action.
A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval
- Martina Kristofova, Y. Aher, J. Aradská
- BiologyBehavioural Brain Research
- 1 May 2018
A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System
- Y. Aher, Saraswathi Subramaniyan, G. Lubec
- Biology, PsychologyFrontiers in Behavioral Neuroscience
- 22 February 2016
The effects upon cognition of a chemically synthesized novel MAT inhibiting compound 2-(benzhydrylsulfinylmethyl)-4-methylthiazole (named as CE-104) is examined to propose a possible mechanism for the observed learning and memory enhancement in the RAM.
A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3
- Sivaprakasam R Saroja, Y. Aher, Predrag Kalaba, Nilima Y. Aher, G. Lubec
- Biology, ChemistryBehavioural Brain Research
- 1 October 2016
A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat
- Ahmed M. Hussein, Y. Aher, Predrag Kalaba, Nilima Y. Aher, G. Lubec
- Biology, PsychologyBehavioural Brain Research
- 14 August 2017
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