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Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines
TLDR
Correlations between WME and latency in the RAM and spine density revealed a link between spine numbers and performance inThe RAM, and the study shows that spine numbers are significantly increased in the trained group, an observation that may suggest the use of this method representing a morphological parameter for memory formation studies in theRAM. Expand
A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes
TLDR
CE-103 was shown to enhance spatial WM and DA reuptake inhibition with subsequent modulation of D1-3 receptors is proposed as a possible mechanism of action. Expand
Frontal cortex and hippocampus neurotransmitter receptor complex level parallels spatial memory performance in the radial arm maze
TLDR
Two distinct RCs were paralleling performance in the RAM which is relevant for interpretation of previous and design of future work on RCs in memory studies. Expand
3D-QSAR studies of substituted 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas as CCR5 receptor antagonists
TLDR
Some key features in the series that are responsible for CCR5 antagonistic activity may be used to design more potent 1-(3,3-diphenylpropyl)-piperidinyl derivatives and predict their activity prior to synthesis. Expand
Individual Differences in Male Rats in a Behavioral Test Battery: A Multivariate Statistical Approach
TLDR
A multivariate approach (principal component analysis) was applied to analyse the behavioral data of 162 male adult Sprague-Dawley rats that underwent a behavioral test battery including commonly used tests for spatial learning and memory and different behavioral patterns as well as for motor abilities. Expand
The effect of modafinil on the rat dopamine transporter and dopamine receptors D1–D3 paralleling cognitive enhancement in the radial arm maze
TLDR
Modafinil was shown to enhance spatial WM in the rat in a well-documented paradigm at all the three doses and dopamine reuptake inhibition with subsequent modulation of D1–3-CC is proposed as a possible mechanism of action. Expand
A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval
TLDR
Dopamine reuptake inhibition by CE‐123 may represent a novel and improved stimulant therapeutic for impairments of cognitive functions and enhance memory performance in a rat model. Expand
A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System
TLDR
The effects upon cognition of a chemically synthesized novel MAT inhibiting compound 2-(benzhydrylsulfinylmethyl)-4-methylthiazole (named as CE-104) is examined to propose a possible mechanism for the observed learning and memory enhancement in the RAM. Expand
A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3
TLDR
Dopamine re-uptake inhibition along with modulations in dopamine receptors are proposed as potential underlying mechanisms and CE-111 was identified as effective to improve memory performance in the RAM. Expand
R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity
TLDR
The results support the notion that LTP-like synaptic plasticity processes could be one of the factors contributing to the cognitive enhancing effects of spatial memory traces and D1R may play an important regulatory role in these processes. Expand
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