Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)
Criteria that support the diagnosis of progressive supranuclear palsy, and that exclude diseases often confused with PSP, are presented.
Partially overlapping neural networks for real and imagined hand movements.
Results suggest that a specific neuronal substrate is involved in the processing of hand motor representations in the form of cortico-subcortical areas.
The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.
The spatiotemporal progression of neuronal loss related to disease duration can be drawn in the substantia nigra pars compacta for each Parkinson's disease patient: depletion begins in the main pocket (nigrosome 1) and then spreads to other nigrosomes and the matrix along rostral, medial and dorsal axes of progression.
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
- P. Redgrave, Manuel Rodriguez, J. Obeso
- Psychology, BiologyNature Reviews Neuroscience
- 14 October 2010
In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour, and patients may be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum.
The Mental Representation of Hand Movements After Parietal Cortex Damage
- A. Sirigu, J. Duhamel, L. Cohen, B. Pillon, Bruno Dubois, Y. Agid
- Psychology, BiologyScience
- 13 September 1996
Patients with lesions restricted to the parietal cortex were found to be impaired selectively at predicting, through mental imagery, the time necessary to perform differentiated finger movements and visually guided pointing gestures, in comparison to normal individuals and to a patient with damage to the primary motor area.
Clinical and genetic abnormalities in patients with Friedreich's ataxia.
The clinical spectrum of Friedreich's ataxia is broader than previously recognized, and the direct molecular test for the GAA expansion on chromosome 9 is useful for diagnosis, determination of prognosis, and genetic counseling.
Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.
This first multicentre study assessing the long-term efficacy of either STN or GPi stimulation shows a significant and substantial clinically important therapeutic benefit for at least 3-4 years in a large cohort of patients with severe Parkinson's disease.
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia.
An increase in total iron content appears to be a response to neurodegeneration in affected basal ganglia regions in a number of movement disorders, suggesting an alteration of iron handling in the substantia nigra in PD.
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
Quantitative analysis of neuromelanin-pigmented neurons in control and parkinsonian midbrains demonstrates that the dopamine-containing cell groups of the normal human midbrain differ markedly from each other in the percentage of neurmelan in-pIGmented neurons they contain, and suggests a selective vulnerability of the neuromelsin- pigmented subpopulation of dopamine- containing mesencephalic neurons in Parkinson's disease.
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.