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Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)
To improve the specificity and sensitivity of the clinical diagnosis of progressive supranuclear palsy (PSP, Steele-Richardson-Olszewski syndrome), the National Institute of Neurological DisordersExpand
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The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.
To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of calbindin D(28K) immunostaining to subdivide theExpand
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Partially overlapping neural networks for real and imagined hand movements.
Neuroimagery findings have shown similar cerebral networks associated with imagination and execution of a movement. On the other hand, neuropsychological studies of parietal-lesioned patients suggestExpand
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Clinical and genetic abnormalities in patients with Friedreich's ataxia.
BACKGROUND Friedreich's ataxia, the most common inherited ataxia, is associated with a mutation that consists of an unstable expansion of GAA repeats in the first intron of the frataxin gene onExpand
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The Mental Representation of Hand Movements After Parietal Cortex Damage
Recent neuroimagery findings showed that the patterns of cerebral activation during the mental rehearsal of a motor act are similar to those produced by its actual execution. This concurs with theExpand
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Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.
Deep brain stimulation (DBS) is associated with significant improvement of motor complications in patients with severe Parkinson's disease after some 6-12 months of treatment. Long-term results in aExpand
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Parkinson’s disease and sleepiness: An integral part of PD
ObjectiveTo investigate the potential causes of excessive daytime sleepiness in patients with PD—poor sleep quality, abnormal sleep–wakefulness control, and treatment with dopaminergic agents.Expand
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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
In idiopathic Parkinson's disease massive cell death occurs in the dopamine-containing substantia nigra1,24. A link between the vulnerability of nigral neurons and the prominent pigmentation of theExpand
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Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
Abstract: Polyunsaturated fatty acid (PUFA) levels (an index of the amount of substrate available for lipid peroxidation) were measured in several brain regions from patients who died withExpand
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Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease
Abstract: Levels of iron, copper, zinc, manganese, and lead were measured by inductively coupled plasma spectroscopy in parkinsonian and age‐matched control brain tissue. There was 31‐35% increase inExpand
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