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BRCA1 germline mutations may be associated with reduced ovarian reserve.
BRCA1 carriers have lower age- and BMI-adjusted serum AMH levels compared with women without BRCA mutations, and this results contribute to the current body of literature regarding BRCa carriers and their reproductive outcomes. Expand
Birth Plans: What Matters for Birth Experience Satisfaction.
Having a higher number of requests fulfilled was positively associated with birth experience satisfaction, while having a high number of Requests fulfilled was inversely associated withBirth experience satisfaction. Expand
Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse
- Y. Afshar, Jae-Wook Jeong, +6 authors A. Fazleabas
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 January 2012
The results demonstrate that the preimplantation uterus relies on Notch signaling to inhibit apoptosis of stromal fibroblasts and regulate cell cycle progression, which together promotes successful decidualization. Expand
Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates.
It is proposed that in the endometrium, Notch has a dual role during the window of uterine receptivity, and down-regulation may be critical for the transition of stromal fibroblast to decidual cells, which is essential for the establishment of a successful pregnancy. Expand
Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
A COOH-terminally truncated variant (v5), which consists of the NH(2)-terminal OB folds and the central region of unknown function, was found to protect telomeres and prevent cellular senescence as efficiently as v1, suggesting its role in chromosome stability associated with MMR deficiency. Expand
A Cross-Cultural Investigation of the Role of Foot Size in Physical Attractiveness
- D. M. Fessler, D. Nettle, +12 authors Asta Zbarauskaitė
- Psychology, Medicine
- Archives of sexual behavior
- 1 June 2005
Preliminary support is provided for the hypothesis that humans possess an evolved preference for small feet in females by examining judgments of attractiveness in nine cultures. Expand
Childbirth Education Class and Birth Plans Are Associated with a Vaginal Delivery
Attending CBE class and/or having a birth plan were associated with a vaginal delivery, and it is suggested that patient education and birth preparation may influence the mode of delivery. Expand
Changes in Eutopic Endometrial Gene Expression During the Progression of Experimental Endometriosis in the Baboon, Papio Anubis1
- Y. Afshar, J. Hastings, Damian Roqueiro, Jae-Wook Jeong, L. Giudice, A. Fazleabas
- Biology, Medicine
- Biology of reproduction
- 1 February 2013
Molecular changes in the eutopic endometrium, associated with endometiosis, are directly impacted by endometriotic lesions, providing strong evidence that it is the disease rather than inherent defective endometrial that results in aberrant gene expression in the Eutopicendometrium. Expand
Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4
- N. Joshi, E. Miyadahira, +5 authors A. Fazleabas
- The Journal of clinical endocrinology and…
- 25 October 2016
It is demonstrated that miR-29c expression is increased in EuE of baboons and women with endometriosis, which might contribute to a compromised progesterone response by diminishing the levels of FKBP4. Expand
The role of chorionic gonadotropin and Notch1 in implantation
- Y. Afshar, A. Stanculescu, L. Miele, A. Fazleabas
- Biology, Medicine
- Journal of Assisted Reproduction and Genetics
- 7 July 2007
It is suggested that chorionic gonadotropin and Notch1 coordinately regulate decidualization by preventing apoptosis of endometrial stromal fibroblasts, averting uterine sloughing, and promoting cell survival and differentiation into the decidUALized phenotype, which is critical for the maintenance of pregnancy. Expand