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Alterations of nitric oxide synthase expression with aging and hypertension in rats.
The decline of eNOS activity and/or expression may contribute to the development of hypertension, whereas the increase of iNOS expression may be a consequence of the pathological state of vessels associated with hypertension in SHR.
Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats.
Data demonstrate that chronic exercise increases EDRF/EDHF production (presumably by increasing endothelial shear stress), and may contribute to the enhanced effects of post-exercise hypotension.
Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats.
An increased production of NO in SHR, which was further enhanced by LPS, is attributed to a basal expression of NOS II, Interestingly, an expression of inducible NO synthase (NOS II) protein was only observed inSHR, and furtherEnhanced by treated rats with LPS.
Losartan attenuates myocardial ischemia-induced ventricular arrythmias and reperfusion injury in spontaneously hypertensive rats.
It is demonstrated that the low and intermediate doses of losartan significantly decreased the incidence of ventricular fibrillation and mortality during the ischemic period induced by left coronary artery occlusion and a significant reduction in infarct size was noted.
Interleukin-1 in ischemia-reperfusion acute lung injury.
It appears that IL-1 may have an important role in I/R lung injury as shown in the results of the present study.
Angiotensinogen gene polymorphism is associated with insulin resistance in nondiabetic men with or without coronary heart disease.
It is suggested that the angiotensinogen T174M allele might be associated with insulin resistance in nondiabetic men with and without CHD.
Antiplatelet effect of amlodipine: a possible mechanism through a nitric oxide-mediated process.
It is proposed that the antiaggregatory mechanisms of amlodipine might be mediated, in part, by a NO-cyclic GMP process accompanied by the inhibition of TXB2 formation in platelets.
Cytokines and cell surface markers in prediction of cardiac allograft rejection.
Monitoring lymphocyte IL-2R/CD4 and HLA-DR/CD3 levels is useful in predicting cardiac transplant rejection, according to serum levels of cytokines and cell surface markers after heart transplantation.
Analysis of 109 cases of infective endocarditis in a tertiary care hospital.
The Duke criteria are more sensitive than the von Reyn criteria for diagnosis of infective endocarditis and indicated that patients with discernible valvular vegetation on echocardiogram had a high mortality rate and occurrence of peripheral or organ embolic events.
Acute myocarditis as an initial manifestation of systemic lupus erythematosus: a case report.
A rare case of systemic lupus erythematosus with initial manifestation of myocarditis is reported here, found in a 24-year-old female who presented first with an episode of exertional dyspnea, later