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Ultraconserved elements have been suggested to retain extended perfect sequence identity between the human, mouse, and rat genomes due to essential functional properties. To investigate the necessities of these elements in vivo, we removed four noncoding ultraconserved elements (ranging in length from 222 to 731 base pairs) from the mouse genome. To(More)
—Inspired from the biological immune system, we propose a local concentration (LC)-based feature extraction approach for anti-spam. The LC approach is considered to be able to effectively extract position-correlated information from messages by transforming each area of a message to a corresponding LC feature. Two implementation strategies of the LC(More)
Sequence polymorphisms in a 58-kilobase (kb) interval on chromosome 9p21 confer a markedly increased risk of coronary artery disease (CAD), the leading cause of death worldwide. The variants have a substantial effect on the epidemiology of CAD and other life-threatening vascular conditions because nearly one-quarter of Caucasians are homozygous for risk(More)
Automatic segmentation of cerebral cortex in magnetic resonance imaging (MRI) is a challenging problem in understanding brain anatomy and functions. The difficulty is mainly due to variable brain structures, various MRI artifacts and restrictive body scanning methods. This paper describes a hybrid model-based method for obtaining an accurate and(More)
Moment invariants are invariant under shifting, scaling and rotation. They are widely used in pattern recognition because of their discrimination power and robustness. HMM method is a natural and highly reliable way of recognition. In this paper, we have proposed a method of using moment invariants as features and HMM as recognition method in facial(More)
Details are presented of a low cost augmented-reality system for the simulation of ultrasound guided needle insertion procedures (tissue biopsy, abscess drainage, nephrostomy etc.) for interventional radiology education and training. The system comprises physical elements; a mannequin, a mock ultrasound probe and a needle, and software elements; generating(More)
The accurate and comprehensive identification of functional regulatory sequences in mammalian genomes remains a major challenge. Here we describe site-specific integration fluorescence-activated cell sorting followed by sequencing (SIF-seq), an unbiased, medium-throughput functional assay for the discovery of distant-acting enhancers. Targeted single-copy(More)