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Despite their structural resemblance, a pair of cyclic halogenated compounds, 1-chloro-1,2,2-trifluorocyclobutane (F3) and 1,2-dichlorohexafluorocyclobutane (F6), exhibit completely different… Continue Reading
A practical design for a high-pass birdcage resonator is presented. Precision seamless telescoping tubes were used for easy tuning of resonant frequency by adjusting the length of the coils. Three… Continue Reading
New lines of evidence suggest that volatile anesthetics interact specifically with proteins. Direct binding analysis, however, has been largely limited to soluble proteins. In this study, specific… Continue Reading
Because a strong correlation exists between the potency of general anesthetics and their ability to dissolve in oil, a lipophilic site of action is often assumed. We show here that a lipophilic… Continue Reading
There is a distinct possibility that general anesthetics exert their action on the postsynaptic receptor channels. The structural requirements for anesthetic binding in transmembrane channels,… Continue Reading
Whether proteins or lipids are the primary target sites for general anesthetic action has engendered considerable debate. Recent in vivo studies have shown that the S(+) and R(-) enantiomers of… Continue Reading
1. The usefulness of nonanesthetics in the study of mechanisms of general anesthesia lies in the possibility to identify the unifying characteristics of molecular sites that are shared by the… Continue Reading
BACKGROUND Determination of macroscopic and microscopic distribution of general anesthetics can facilitate identification of anatomic, cellular, and molecular loci of anesthetic action. Previous… Continue Reading
In the presence of reactive alkali metal hydrides, nitriles can be cyclotrimerized to give 2,4,6-trisubstituted-1,3,5-triazines and 2,4,6-trisubstituted imidazoles in moderate yield.
Superfine powders of alkali metal hydrides of nanometric size exhibit very high reactivity in the hydrogenolysis of aryl halides.