Y. Wen

Learn More
In animal cells, microtubules (MTs) of the mitotic apparatus (MA) communicate with the cell cortex to stimulate cytokinesis; however, the molecular nature of this stimulus remains elusive . A signal for cytokinesis likely involves the MT plus end binding family of proteins, which includes EB1, p150glued, APC, LIS1, and CLIP-170. These proteins modulate MT(More)
In order to understand the causal mechanism of disease aggregates peculiar to place and ethnicity, mortality data of Yanji city, China (1993) were collected, examined for validity and analyzed. Age standardized, age specific mortality rates and ten leading causes of death were compared with 1993 Korean mortality statistics. Age standardized mortality rates(More)
OBJECTIVES The molecular mechanism of rheumatoid arthritis (RA) remains elusive. We conducted a protein-protein interaction network-based integrative analysis of genome-wide association studies (GWAS) and gene expression profiles of RA. METHODS We first performed a dense search of RA-associated gene modules by integrating a large GWAS meta-analysis(More)
The Hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), nonstructural protein 5B (NS5B), is anchored in the membrane through a C-terminal helix. A sequence of ca. 12 residues that connects the catalytically competent portion of the RdRp and the C-terminal helix, the juxtamembrane sequence (JMS), has a poorly defined role in RdRp function in a large(More)
Simple spikes and complex spikes are two distinguishing features in neurons of the cerebellar cortex; the motor learning and memory processes are dependent on these firing patterns. In our research, the detailed firing behaviors of Purkinje cells were investigated using a computer compartmental neuronal model. By means of application of numerical stimuli,(More)
Purpose. The purpose of this study was to compare the surgical and pathological variables which impact rate of re-excision following breast conserving therapy (BCS) with or without concurrent additional margin excision (AM). Methods. The pathology database was queried for all patients with DCIS from January 2004 to September 2008. Pathologic assessment(More)
In this paper we propose a new design criterion for subband adaptive filters (SAFs). The proposed multiple-constraint optimization criterion is based on the principle of minimal disturbance, where the multiple constraints are imposed on the updated subband filter outputs. Compared to the classical fullband least-mean-square (LMS) algorithm, the sub-band(More)
  • 1