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Calcium/calmodulin inhibition of basic-helix-loop-helix transcription factor domains.

• Brit Corneliussen, Magnus Holm, +4 authors Thomas Grundström
• Nature
• 1994

The ubiquitous Ca(2+)-binding protein calmodulin (CaM) is a key protein in Ca2+ homeostasis and activation of eukaryotic cells. CaM is the molecular link between free Ca2+ in the cell and the… (More)

Mutational effects on the cooperativity of Ca2+ binding in calmodulin.

• Y Waltersson, Sara Linse, Priscille Brodin, Thomas Grundström
• Biochemistry
• 1993

The importance of the aspartate ligand in the +Y Ca2+ coordinating position of two EF-hands of calmodulin has been investigated. Synthetic calmodulin genes were used to produce engineered proteins… (More)

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