Learn More
Glutathione S-transferase (GST) Ya subunit gene expression is induced in mammalian tissues by two types of chemical agents: (i) planar aromatic compounds (e.g., 3-methylcholanthrene, beta-naphthoflavone, and 2,3,7,8-tetrachlorodibenzo-p- dioxin) and (ii) electrophiles (e.g., trans-4-phenyl-3-buten-2-one and dimethyl fumarate) or compounds easily oxidized to(More)
A mouse glutathione S-transferase gene encoding the Ya subunit was isolated and sequenced. The gene spans about 11 kb, contains seven exons, and encodes an mRNA of 841 nucleotides. Promoter elements, TATA and CAAT box sequences, were located 32 and 70 nucleotides upstream from the initiation of transcription site. The mRNA coding sequences of the mouse gene(More)
We have recently reported the complete sequence of a mouse glutathione Stransferase Ya subunit gene, including a small portion of the 5'-flanking sequence with the transcription initiation site (1 ). The 5'-flanking region of this gene, 1594 base pairs upstream the initiation of transcription site, has now been determined. Promoter elements such as modified(More)
  • 1