Y. Shinohara

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Lumican belongs to the small leucine-rich repeat proteoglycan (SLRP) gene family and has been reported to exist in the cornea, inter-vertebral disc and tendon. Lumican plays a significant role in the assembly and regulation of collagen fibres. The human temporo-mandibular joint (TMJ) disc is made up of fibrocartilage with an extracellular matrix (ECM)(More)
Small leucine-rich repeat proteoglycans (SLRP) are present in the extracellular matrix of the temporomandibular joint (TMJ) disc. Lumican and fibromodulin, classified as class 2 SLRPs, play important roles in TMJ assembly, proliferation and inflammation. Degenerative change in the TMJ disc gives rise to the process of internal derangement (ID). In this(More)
Tenascin-C (TNC) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has been reported that TNC is expressed in inflamed synovial membranes and deformed discs of temporomandibular joint (TMJ) disorder. However, the role of TNC in TMJ is not fully known. In this study, the role of TNC in fibrous(More)
We report a first-principles computational method to describe many-electron dynamics in crystalline solids. The method is based on the time-dependent density functional theory, solving the time-dependent Kohn-Sham equation in real time and real space. The calculation is efficiently parallelized by distributing computations of different k-points among(More)
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