Y. Sakagami

Learn More
Tauopathy is a pathological condition with an abnormal intracellular accumulation of tau protein in neurons and glias, which is a feature of Alzheimer's disease (AD) as well as frontotemporal lobar degenerations (FTLD). Recent reports showed that tauopathy occupies an important position for pathological process of dementia generally. Previously, we reported(More)
We recently demonstrated that endoplasmic reticulum (ER) stress induces sigma-1 receptor (Sig-1R) expression through the PERK pathway, which is one of the cell's responses to ER stress. In addition, it has been demonstrated that induction of Sig-1R can repress cell death signaling. Fluvoxamine (Flv) is a selective serotonin reuptake inhibitor (SSRI) with a(More)
Japanese is a peculiar language among the thousands of languages in the world. There exist only two of the same class! Japanese and Korean. Japanese is written both in Chinese characters (ideograph) and in Kana (Katakana and HAragana-phonetlo symbols) In mixture without any space. Moreover, 0hi-neee characters in Japanese have, in most cases, several(More)
  • 1