Y. Rideau

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Human muscle cells obtained from biopsy specimens were grown in a primary culture system and electrophysiologically studied. Whole cell patch-clamp recordings revealed the presence of two types of calcium currents: (i) a low-threshold (-60 mV) one (ICa, T) with fast activation and inactivation kinetics (time-to-peak: 39 ms at -30 mV); and (ii) a(More)
The early pathophysiologic study showed increasing evidence that autoimmunity is implicated in the pathogenesis of neu-romyotonia. Antibodies to voltage gated potassium channel were detected in the serum of patients who had peripherical nerves hy-perexcitability and also Morvan's disease or limbic encephalitis. These discoveries offered new approaches to(More)
A third type of calcium current could be recorded on a non-negligible number of human skeletal muscle cells (normal and Duchenne dystrophic (DMD)) in primary culture. This transient current exhibited a maximum at 0 mV, a time-to-peak around 30 ms, an inactivation time constant around 70 ms and was insensitive to nifedipine. On these basis, it differentiates(More)
Electromyocartographic analysis of the extension of the leg in different positions has shown that: - on the whole energy developped by all superficial muscles of the thigh is more important in the position of dorsal decubitus than in a seated position; - functionnal activity of the rectus femoris muscle varies according to different subjects. Its activity(More)