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Previous studies have clearly shown that the progressive decrease of growth hormone (GH) secretion occurring during ageing is coupled with a reduced responsiveness of pituitary GHRH receptors both in terms of GH secretion and activation of the adenylyl cyclase (AC), in the presence of increased basal values of the enzyme. The mechanism(s) subserving the(More)
THE persistence of donor leukocvtes in recipients after transplantation (chimerism) has been postulated as the basis for graft acceptance. I.: There have been direct efforts to augment chimerism in order to increase the chance of graft acceptance. even though the mechanism of the bidirectional modulation between host and chimeric cells to achieve(More)
We previously found that endothelin-1(1-31) (ET-1(1-31)) exhibited a pro-arrhythmogenic effect in isolated rat hearts. In this study, we further investigated the effects of ET-1(1-31) on a cell viability and observed [Ca(2+)](i) in cultured cardiomyocytes. Cultured neonatal rat cardiomyocytes were treated with 0.1, 1, and 10 nM ET-1(1-31) for 24h in the(More)
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