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Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07).(More)
OBJECTIVES To evaluate the efficacy and safety of lithium in the treatment of thyrotoxicosis, and to study the dose and serum levels at which therapeutic response occurs. DESIGN Retrospective study. SETTING Thyroid clinic of a regional hospital in Hong Kong. PATIENTS Thirteen patients with thyrotoxicosis pending therapy with radioiodine or surgery, in(More)
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