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Background Llamas raise two different types of antibodies against foreign invaders, the conventional antibodies and the heavy chain devoid of light chain antibodies. We have used llama to raise and select the latter class antibodies (VHH) against HIV-1. The advantage of using VHHs is the relative ease to construct large (>108) and nearly 100% functional(More)
Results 2H10 binds to the intermediate conformation of gp41 with medium nanomolar affinity. Construction of 2H10 biheads (bi-2H10) increases the binding affinity by a factor of 20. Bi-2H10 neutralizes various sensitive and resistant HIV-1 strains, as well as SHIV strains in a TZM-bl cell assay. We further present structural data from crystallographic and(More)
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