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The phosphorylation state of the proteins, regulated by phosphatases and kinases, plays an important role in signal transduction and long-term changes in neuronal excitability. In neurons, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and calcineurin (CN) are attached to a scaffold protein, A kinase anchoring protein (AKAP), thought to anchor(More)
Background Chromosomal instability, which often occurs as a random event in an uncontrollable manner, is a key characteristic of Chinese Hamster Ovary (CHO) cells. This often complicates the process of establishing stable, high antibody-producing CHO cell lines. We previously found that the abnormal increase of chromosome number is linked to increased(More)
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