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Calorie restriction (CR) extends lifespan in a remarkable range of organisms. However, the mechanisms of CR related to the longevity effects are not fully elucidated to date. Using human fibroblast Hs68 (Hs68) cells cultured at a lower level of medium glucose (i.e., glucose restriction; GR) to mimic CR, we investigated the crucial role of nicotinamide(More)
OBJECTIVES To investigate the association between the trends of CT utilisation in an emergency department (ED) and changes in clinical imaging practice and patients' disposition. SETTING A hospital-based retrospective observational study of a public 1520-bed referral medical centre in Taiwan. PARTICIPANTS Adult ED visits (aged ≥18 years) during(More)
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