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A regulatory SNP at position −899 in CDKN1A is associated with systemic lupus erythematosus and lupus nephritis
- K. Kim, Y-K Sung, C. Kang, C-B Choi, C. Kang, S.-C. Bae
- Medicine, Biology
- Genes and Immunity
- 5 March 2009
The CDKN1A gene encoding a cell cycle inhibitor, p21(WAF1/CIP1), is located in the systemic lupus erythematosus (SLE) susceptibility locus on chromosome 6p21.2. Decreased cellular levels of p21 are… Expand
Genetic studies of systemic lupus erythematosus in Asia: where are we now?
There have been many genetic studies of systemic lupus erythematosus (SLE) in Asia, but the status of SLE in Asia remains unclear. Genes that have been associated with SLE in Caucasians have shown… Expand
MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients.
OBJECTIVE The MER receptor tyrosine kinase (MERTK) gene is critical for the efficient clearance of apoptotic cells and has implications for inflammation and autoimmune diseases such as systemic lupus… Expand
Precuneus hypoperfusion plays an important role in memory impairment of patients with systemic lupus erythematosus
The present study was designed to identify regional cerebral blood flow (rCBF) abnormalities in systemic lupus erythematosus (SLE) patients with memory impairments. Nineteen SLE patients (mean age… Expand
Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus.
OBJECTIVE The objective of this study was to confirm whether polymorphisms of the poly(ADP-ribose) polymerase gene (PARP) are associated with genetic susceptibility to systemic lupus erythematosus… Expand
Interleukin-10 gene polymorphisms are associated with the SLICC/ACR Damage Index in systemic lupus erythematosus.
OBJECTIVE Overproduction of interleukin-10 (IL-10) is a pivotal feature in the pathophysiology of systemic lupus erythematosus (SLE). We examined the IL10 genotype of Korean patients with SLE and… Expand
An unusual form of cutaneous lupus erythematosus over the eyelid in systemic lupus erythematosus.
Sir — In the clinical features of cutaneous lupus erythematosus (CLE), the discoid erythema and some other clinical forms occur mostly on the exposed part, usually on the head and neck areas. We… Expand
AB1193 Developing the korean educational needs assessment tool (KOREAN-ENAT) in rheumatoid arthritis: a cross-cultural validation using rasch analysis
Background The Educational Needs Assessment Tool (ENAT) is a 39-item patient-completed questionnaire designed to help patients identify and prioritize their educational needs. It was originally… Expand