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Background:An elevated neutrophil-to-lymphocyte ratio (NLR) is associated with poor outcome in various tumours. Its prognostic utility in patients with urothelial carcinoma of the bladder (UCB) undergoing radical cystectomy (RC) is yet to be fully elucidated.Methods:A cohort of patients undergoing RC for UCB in a tertiary referral centre between 1992 and(More)
Cancer initiating cells (CICs) are responsible for the unrestrained cell growth and chemoresistance of malignant tumors. Histone demethylation has been shown to be crucial for self-renewal/differentiation of stem cells, but it remains elusive whether lysine-specific demethylase 1 (LSD1) regulates the stemness properties of CICs. Here we report that the(More)
Tetrandrine (TET, 100 mg/kg) injected intraperitoneally could prevent rats from diabetes induced by alloxan. After 48 h of injection of alloxan, the blood sugar of the preventive group decreased from the control value of 25.46 +/- 1.21 mmol/L to 7.63 +/- 0.44 mmol/L (P < 0.001) while the serum insulin level increased to 11.33 +/- 1.97 microU/ml and the(More)
An experimental diabetes model was produced by intravenous injection of alloxan. Verapamil (40 mg/kg) administered intraperitoneally 30 minutes prior to alloxan was able to decrease serum glucose from 22.93 +/- 1.37 mmol/L to 8.79 +/- 0.83 mmol/L after 48 hours of injection of alloxan. Histological findings showed that the number of secretory granules in(More)
Abnormal glucose metabolism (AGM) is common but underestimated in patients with coronary heart disease (CHD). Here, we reported 898 in-hospital patients with primary hypertension (PH) at the university hospitals in developed regions of China. Oral glucose tolerance test (OGTT) was performed in those without known type-2 diabetes mellitus (2-DM). A total of(More)
This study was conducted to investigate the effect of intracerebroventricular administration of adrenomedullin (13-52) [ADM(13-52)], a novel hypotensive peptide, on the hemodynamic parameters of anesthetized rats. ADM(13-52) was administered centrally in a dose of 0.4-3.2 nmol/kg. It provoked marked, prolonged and dose-dependent increases in mean arterial(More)
The dilatant effect of adrenomedullin (ADM), a novel peptide of 52 amino acids, on the mesenteric microvessels and microlymphatics was investigated under microscopic observation. 10(-6) mol/L ADM could also ameliorate alteration of the hemorheology induced by 10(-5) mol/L norepinephrine (NE) or 10(-7) mol/L endothelin (ET). However, this ameliorative(More)
The effect of adrenomedullin (AM) on blood pressure and tension of aortic rings were studied in normal and in either spontaneous or renal hypertensive rats (SHR/RHR). The distribution characteristics of AM in viscera was also investigated. It was found that the hypotensive action of AM was far more prominent in hypertensive than in normotensive rats. The(More)
In this report, reporter gene beta-galactosidase (LacZ) was chosen to compare two different intramuscular gene transfer methods, direct injection and gene suture. Evidence showed that gene suture can produce a higher foreign gene express efficiency in skeletal muscle compared with the direct injection method. The highly efficient eukaryotic expressing(More)
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