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The polymerase chain reaction was used to evaluate minimum residual disease in chronic myelogenous leukaemia (CML) patients after bone-marrow transplantation, by amplification of the transcript of the specific bcr/abl hybrid gene. Strict precautions were taken to avoid contamination. Peripheral blood cells from 22 patients transplanted for haematological… (More)
Sex steroid hormones such as testosterone and oestradiol induce immunomodulation of the and cytosolic binding has been demonstrated in normal and pathological human lymphocytes, (Danel et al., 1981). How the hormones enter the cells is controversial: a "passive" diffusion as described by Peck et al. (1973) or a "facilitated" diffusion as postulated by… (More)
Steroid binding to human lymphocytes was previously detected by a fluorescence assay (Tubiana et al., 1984). In the present study fluorescence assays were carried out with a macromolecular complex constituted by covalently binding steroid to bovine serum albumin (BSA). In this way it was possible to eliminate transmembrane diffusion and confine the study to… (More)
Neurologic complications are frequently observed during HIV-related infections and particularly in AIDS. According to the literature, these complications more often pertain to the central nervous system (CNS) than the peripheral nervous system (PNS). A prospective study was carried out in order to determine the frequency and type of PNS disorders during HIV… (More)
Good immunoprotection was afforded by A9/SEWA somatic hybrid cells in the C3H mouse/C3H Py tumour system, confirming results previously obtained in the A.SW mouse/SEWA tumour system. However, in this study the immunogenicity decreased with increasing serial subculture of the hybrid line and concomitant chromosome loss.
Basophils possess membrane bound IgE molecules, and immunological activation leads to a secretory process with cell degranulation and histamine release. Heterologous anti IgE, concanavaline A, and phytohaemagglutinin are potent non-cytotoxic releasing agents. They operate by a mechanism similar to that of immunological activation. Heavy water is not a… (More)
On the basis of 88 patients examined with CAT, the writers consider the merits of this method of investigation in a study of endocranial complications in blood diseases. Interest in CAT is related in great part to its innoccuousness (making it possible to extend its application to often seriously ill patients) and the precision of the images which are… (More)