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Spinocerebellar ataxia type 1 (SCA1) is one of several neurological disorders caused by a CAG repeat expansion. In SCA1, this expansion produces an abnormally long polyglutamine tract in the protein ataxin-1. Mutant polyglutamine proteins accumulate in neurons, inducing neurodegeneration, but the mechanism underlying this accumulation has been unclear. We(More)
Spinocerebellar ataxia type 1 (SCA1) is one of several neurodegenerative diseases caused by expansion of a polyglutamine tract in the disease protein, in this case, ATAXIN-1 (ATXN1). A key question in the field is whether neurotoxicity is mediated by aberrant, novel interactions with the expanded protein or whether its wild-type functions are augmented to a(More)
Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by expansion of a glutamine tract in ataxin-1 (ATXN1). SCA1 pathogenesis studies support a model in which the expanded glutamine tract causes toxicity by modulating the normal activities of ATXN1. To explore native interactions that modify the toxicity of ATXN1,(More)
One prominent characteristic of product design for injection molded parts is that design and analysis (e.g. flow simulation) go hand-in-hand to ensure that the design is manufacturable by the injection molding process. Despite the wide use of CAD and CAE systems, it is known that communication between the two processes is poor. In this paper we propose a(More)
In recent years, the power systems of many countries have been restructured. Different models of electricity market emerged. A simulator that can serve as an educational tool, an evaluation tool, and a training tool would especially be useful for countries that are contemplating restructuring. A power market has significant requirements on platform(More)
In large area micro hot embossing, process temperature plays a critical role in both the local fidelity of microstructure formation and global uniformity. Micro embossing at the lowest temperature with acceptable fidelity can improve the global flatness after demolding. This paper focuses on polymer deformation and recovery in micro embossing when the(More)