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Scheduling algorithms for control dominated applications have not been widely published. Path-based scheduling was the first attempt to tackle this problem. This approach works well on the benchmark examples. However, it imposes a restriction on the execution order of the operations before scheduling. We alleviate this restriction by representing all the(More)
— Preserving cultural heritage and historic sites is an important problem. These sites are subject to erosion , vandalism, and as long-lived artifacts, they have gone through many phases of construction, damage and repair. It is important to keep an accurate record of these sites using 3-D model building technology as they currently are, so preservationists(More)
In this paper, a new path selection heuristic search algorithm is proposed for connecting two components of vertices. A novel feature of the algorithm is that the <italic>active</italic> terminals (vertices in the net which are not yet connected) are modeled as magnets during the path searching process. The heuristic search algorithm is applied to two(More)
A composite-metaphor interface is a computer interface consisting of a combination of two or more metaphors. As computer systems have become more sophisticated, researchers have proposed the use of multiple metaphors to design computer systems because they would better match the characteristics of complex target systems; however, due to the difficulty of(More)
The inhibition of FMS-like tyrosine kinase 3 (FLT3) activity using small-molecule inhibitors has emerged as a target-based alternative to traditional chemotherapy for the treatment of acute myeloid leukemia (AML). In this study, we report the use of structure-based virtual screening (SBVS), a computer-aided drug design technique for the identification of(More)
We describe the 3D-QSAR-assisted design of an Aurora kinase A inhibitor with improved physicochemical properties, in vitro activity, and in vivo pharmacokinetic profiles over those of the initial lead. Three different 3D-QSAR models were built and validated by using a set of 66 pyrazole (Model I) and furanopyrimidine (Model II) compounds with IC(50) values(More)
A general method of determining the nature of the genotypes in mutants of transformable bacteria with similar phenotypes is discussed. The method is used to identify the genotypic patterns of three mutants of Hemophilus influenzae which are resistant to different levels of streptomycin. A mutant resistant to 700 microg per ml of the antibiotic was found to(More)
The design and synthesis of a quinazoline-based, multi-kinase inhibitor for the treatment of acute myeloid leukemia (AML) and other malignancies is reported. Based on the previously reported furanopyrimidine 3, quinazoline core containing lead 4 was synthesized and found to impart dual FLT3/AURKA inhibition (IC50 = 127/5 nM), as well as improved(More)