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The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo

• Itamar Levinger, Xuzhu Lin, +6 authors Glenn McConell
• Osteoporosis International
• 2015

SummaryWe tested whether GPRC6A, the putative receptor of undercarboxylated osteocalcin (ucOC), is present in mouse muscle and whether ucOC increases insulin sensitivity following ex vivo muscle… (More)

Recombinant Uncarboxylated Osteocalcin Per Se Enhances Mouse Skeletal Muscle Glucose Uptake in both Extensor Digitorum Longus and Soleus Muscles

• Xuzhu Lin, Lewan Parker, +5 authors Itamar Levinger
• Front. Endocrinol.
• 2017

Emerging evidence suggests that undercarboxylated osteocalcin (ucOC) improves muscle glucose uptake in rodents. However, whether ucOC can directly increase glucose uptake in both glycolytic and… (More)

Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin

• Itamar Levinger, Tara C. Brennan-Speranza, +4 authors Bu B. Yeap
• Osteoporosis International
• 2017

Undercarboxylated osteocalcin (ucOC) may play a role in glucose homeostasis and cardiometabolic health. This review examines the epidemiological and interventional evidence associating osteocalcin… (More)

Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats.

• Xuzhu Lin, Erik D Hanson, Andrew C Betik, Tara C. Brennan-Speranza, Alan Hayes, Itamar Levinger
• Journal of bone and mineral research : the…
• 2016

Undercarboxylated osteocalcin (ucOC) has been implicated in skeletal muscle insulin sensitivity and function. However, whether muscle mass and strength loss in atrophic conditions is related to a… (More)

Glucocorticoid-Induced Insulin Resistance in Men Is Associated With Suppressed Undercarboxylated Osteocalcin.

• Lewan Parker, Xuzhu Lin, +8 authors Itamar Levinger
• Journal of bone and mineral research : the…
• 2019

In mice, glucocorticoid-induced insulin resistance occurs largely through impaired osteoblast function and decreased circulating undercarboxylated osteocalcin (ucOC). Whether these mechanisms… (More)

Uncarboxylated Osteocalcin Enhances Glucose Uptake Ex Vivo in Insulin-Stimulated Mouse Oxidative But Not Glycolytic Muscle

• Xuzhu Lin, Lewan Parker, +5 authors Itamar Levinger
• Calcified Tissue International
• 2018

Uncarboxylated osteocalcin (ucOC) stimulates muscle glucose uptake in mice EDL and soleus muscles. However, whether ucOC also exerts a similar effect in insulin-stimulated muscles in a muscle… (More)

Undercarboxylated Osteocalcin Improves Insulin-Stimulated Glucose Uptake in Muscles of Corticosterone-Treated Mice.

• Xuzhu Lin, Lewan Parker, +4 authors Itamar Levinger
• Journal of bone and mineral research : the…
• 2019

Short-term administration of glucocorticoids (GCs) impairs muscle insulin sensitivity at least in part via the reduction of undercarboxylated osteocalcin (ucOC). However, whether ucOC treatment… (More)

Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity

• Xuzhu Lin, Tara C. Brennan-Speranza, Itamar Levinger, Bu B. Yeap
• Nutrients
• 2018

Recent advances have indicated that osteocalcin, and in particular its undercarboxylated form (ucOC), is not only a nutritional biomarker reflective of vitamin K status and an indicator of bone… (More)

Normal increases in insulin-stimulated glucose uptake after ex vivo contraction in neuronal nitric oxide synthase mu (nNOSμ) knockout mice

• Xinmei Zhang, Xuzhu Lin, Glenn McConell
• Pflügers Archiv - European Journal of Physiology
• 2019

Nitric oxide (NO) is involved in skeletal muscle glucose uptake during exercise and also in the increase in insulin sensitivity after exercise. Given that neuronal nitric oxide synthase (NOS) isoform… (More)

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