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Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010-2014).
TLDR
HBV genotypes had no impact on antiviral drug resistance, except for some drug resistance substitutions bias, and Optional initial therapy and subsequent rescue treatment should be based on knowledge of nucleos(t)ide analogue resistance. Expand
Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy
TLDR
These findings provided a rational explanation for genotype shift among ADV-treated CHB patients and suggested the genotype and genotypes shift might be associated with antiviral efficiency. Expand
Lower Mutation Frequency of BCP/Precore Regions in e Antigen-Negative Chronic HBV-Infected Children instead of Adults Patients
TLDR
The frequencies of these HBeAg seroconversion-related mutations were significantly lower in HBe Ag-negative children with CHB than in H beAg-negative adults withCHB, suggesting less impact of mutations in the BCP/precore region on H BeAg serconversion in child patients than adult patients. Expand
LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
  • Xuyang Gong, A-L Huang
  • Chemistry, Medicine
  • European review for medical and pharmacological…
  • 1 November 2019
TLDR
In this research, the down-regulation of LEF-AS1 reduces the proliferation rate and suppresses the invasiveness and metastasis of CRC cells through the LEF -AS1/miR-505/KIF3B axis. Expand
Regulatory roles of miR-593 in the proliferation and invasion of human hepatic carcinoma.
  • Xuyang Gong, A-L Huang
  • Biology, Medicine
  • European review for medical and pharmacological…
  • 1 June 2020
TLDR
It is proposed that miR-593 might be a new potential therapeutic target marker for HCC treatment because of its role in mediating the proliferation, migration and invasion of HCC cells. Expand
[The biological function of auto-induced expression of the hepatitis C virus soluble core protein].
TLDR
Soluble recombinant protein C was successfully expressed by auto-induction, and shown to interact with the HCV NS3 protein, which provides a novel insight into the putative biological activity of this factor in HCV-related molecular processes. Expand
Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin‐4 in alpha‐fetoprotein‐negative hepatocellular carcinoma
TLDR
The value of P53, MutS homologs 2 (MSH2), and tropomyosin‐4 (Tm‐4) combined with inflammatory factors, life‐history traits in the differential diagnosis of alpha‐fetoprotein‐negative hepatocellular carcinoma (AFP‐Negative HCC). Expand