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MicroRNA-let-7e regulates the progression and development of allergic rhinitis by targeting suppressor of cytokine signaling 4 and activating Janus kinase 1/signal transducer and activator of
TLDR
MiR-let-7e may serve an important role in the progression and development of AR, while overexpression of miR- let- 7e had an anti-inflammatory effect by targeting SOCS4, which may be achieved by activation of the JAK1/STAT3 signaling pathway. Expand
Involvement of T-Helper 9 Activation in a Mouse Model of Allergic Rhinitis
TLDR
AR is related to the changes of cytokines in TH1, TH2, TH9, TH17, and Treg, which are improved by IL-9 silencing, which were ameliorated by IL+AR silencing. Expand
Circ_0067835 regulates allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis (AR) via miR-155/GATA3.
TLDR
Inhibiting circ_0067835 could reduce Type2 cytokines and ILC2s levels in AR mice model and targeted and positively regulated miR-155 expression, and GATA3 was a downstream target of mi R-155 and adjusted by circ_067835/miR- 155 axis. Expand
Iloprost inhibits acute allergic nasal inflammation by GATA3 -ILC2 pathway in mice
TLDR
Iloprost may potentially inhibit the proliferation and activation of innate lymphoid cells 2 in mice with acute allergic inflammation, which maybe an effective option for the treatment of acute allergicinflammation related diseases. Expand