Share This Author
The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice
Anesthesia management of surgery for sigmoid perforation and acute peritonitis patient following heart transplantation: case report.
A case in which a patient underwent emergency laparotomy for acute peritonitis and sigmoid perforation under general anesthesia with a history of heart transplantation is described, aiming to provide some guidance for those scheduled for non-cardiac surgery after heart transplant.
Intrathecal Injection of the Peptide Myr-NR2B9c Attenuates Bone Cancer Pain Via Perturbing N-Methyl-D-Aspartate Receptor-PSD-95 Protein Interactions in Mice
This approach may circumvent the negative consequences associated with blocking NMDARs, and may be a novel strategy for the treatment of bone cancer pain.
Neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction
The risk factors for delirium in older orthopedic surgery patients in post-anesthesia care unit after general anesthesia
It is revealed that age may serve as a potential risk factor for delirium via logistic regression analysis for variables observed statistically significant in comparisons between groups (P=0.005,OR=1.231).
STAT3 Involved in Cellular Vulnerability to Isoflurane
Results indicated that specific regulation of STAT3 was closely related with the cellular vulnerability to isoflurane, and the blockage of calcineurin activity ameliorated neural apoptosis, dendritic spine impairment and cognitive dysfunction induced by isofLurane.
Effect of repeated intrathecal injection of ifenprodil on pain behaviors in mice with bone cancer pain
Repeated intratheal injection of ifenprodil can efficiently relieve spontaneous lifting behaviors, mechanicalhyperalgia and thermal hyperalgia and decrease the expression of lumbar intumescentia NR2B in the mouse model of bone cancer pain.
Analgesic efficacy of intrathecal injection of competitive kinesin superfamily protein 17 antagonist in a mouse model of bone cancer pain
Intrathecal RC-13,a competitive kinesin superfamily protein 17 antagonist, has a good analgesic efficacy in a mouse model of bone cancer pain and the efficacy is dose-dependent.
Effect of intrathecal injection of magnesium sulfate on pain behavior in bone cancer pain mouse
Intrathecal injection MgSO4 can effectively attenuate bone cancer pain dose-dependently and amplify the analgesic effect of subliminal morphine, and reverse quantification of spontaneous flinches, mechanical allodynia and thermal hyperalgesia which were induced by inoculation.
Participation of spinal CaMKII-NR2B signal pathway in the development of bone cancer pain in mice
Intrathecal injection of KN93 can attenuateBone cancer pain in mice through inhibiting NR2B with a time-dependent manner and spinal CaMKII-NR2B pathway may participate in the development of bone cancer pain.