Xuhong Zhou

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OBJECTIVE To study the molecular pathogenesis of protein C (PC) deficiency in a patient with pulmonary embolism and in his family members. METHODS Anticoagulated blood samples were collected from the proband and his family members to detect PC, PS and AT activities. PC antigen level was measured using ELISA. The genomic DNA was extracted to amplify all(More)
While some long noncoding RNAs (lncRNAs) might promote nasopharyngeal carcinoma (NPC) initiation and progression, the involved molecular mechanisms remain largely unclear. Here, we discovered the novel LncRNA, prostate cancer associated transcript 7 (PCAT7), which was overexpressed and associated with worse prognosis in NPC. Decreased PCAT7 expression was(More)
OBJECTIVE To investigate the expression of Skp2 and p27 and their association with clinical, histologic characteristics and prognosis in laryngeal squamous cell carcinoma (LSCC), the correlation between expression of Skp2 and p27 in LSCC. METHOD Skp2 protein and p27 protein were examined by using immunohistochemical SP staining method in 20 cases of(More)
OBJECTIVE To investigate the expressions of p53 and PCNA by inhibition of hTERT with siRNA in xenografted laryngeal squamous carcinoma in nude mice. METHOD pshRNA involved fluorescein gene was synthesized according to the sequence of hTERT cDNA. The xenografted tumor in nude mice was established by using human laryngeal squamous carcinoma cell line(More)
OBJECTIVE To evaluate the expression of IGF-1R protein and its clinical signification in nasopharyngeal carcinoma. METHOD SP immunohistochemical staining was performed to detect the expression of IGF-1R in 63 cases of NPC and 21 inflammatory nasopharyngeal mucosa; and the expression of IGF-1R in three NPC cell lines and chronic nasopharyngitis tissues was(More)
OBJECTIVE To compare the effectiveness of sequential treatment for subjective and objective benign paroxysmal positional vertigo(BPPV). METHOD The efficacy of sequential treatment for nineteen vertical semicircular canal S-BPPV patients(Group A) and forty-five vertical semicircular canal O-BPPV patients(Group B) who were admitted to our hospital between(More)
OBJECTIVE To investigate the expression of FLIP and PTEN in laryngeal Squamous cell carcinoma (LSCC), and the relationship between FLIP and PTEN. METHOD The protein expression of FLIP and PTEN were examined by using immunohistochemical method in 45 cases of LSCC and 15 cases of para-carcinoma tissues. RESULT FLIP protein positive expressive rate in the(More)
OBJECTIVES Epidermal growth factor (EGF) and type 1 insulin-like growth factor (IGF-1) receptors play an important role in the growth and apoptosis of nasopharyngeal carcinoma (NPC). They were separately found to be associated with prognosis in patients with NPC. To date, their expression correlation and clinicopathologic significance have never been(More)
OBJECTIVE To investigate the expression of miRNA-204 in patients with NPC and to analyze the as- sociation of the expression with the cIinicopathologicaI features and prognosis. METHOD The expression levels of miRNA-204 in 50 patients with NPC and 40 patients with nasopharyngeal chronic inflammation were detected by using stem-loop real-time reverse(More)
OBJECTIVE To explore the clinical manifestation and diagnosis as well as the treatment of ectopic meningioma of maxillary sinus in children. METHOD Four cases of ectopic meningioma of maxillary sinus in children were investigated with retrospective analysis and review of the literatures. RESULT All the four cases presented progressing nasal obstruction(More)