Learn More
OBJECTIVE Traditional Chinese medicine (TCM) is a scientific discipline, which develops the related theories from the long-term clinical practices. The large-scale clinical data are the core empirical knowledge source for TCM research. This paper introduces a clinical data warehouse (CDW) system, which incorporates the structured electronic medical record(More)
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA). Here we performed a genome-wide association study meta-analysis in a total of(More)
Extracting meaningful information and knowledge from free text is the subject of considerable research interest in the machine learning and data mining fields. Text data mining (or text mining) has become one of the most active research sub-fields in data mining. Significant developments in the area of biomedical text mining during the past years have(More)
OBJECTIVE As a complementary medical system to Western medicine, traditional Chinese medicine (TCM) provides a unique theoretical and practical approach to the treatment of diseases over thousands of years. Confronted with the increasing popularity of TCM and the huge volume of TCM data, historically accumulated and recently obtained, there is an urgent(More)
Traditional Chinese medicine (TCM) as a complete knowledge system researches into human health conditions via a different approach compared to orthodox medicine. We are developing a unified traditional Chinese medical language system (UTCMLS) through an ontology approach that will support TCM language knowledge storage, concept-based information retrieval(More)
We present a novel text mining approach to uncover the functional gene relationships, maybe, temporal and spatial functional modular interaction networks, from MEDLINE in large scale. Other than the regular approaches, which only consider the reductionistic molecular biological knowledge in MEDLINE, we use TCM knowledge(e.g. Symptom Complex) and the 50,000(More)
OBJECTIVE The amount of biomedical data in different disciplines is growing at an exponential rate. Integrating these significant knowledge sources to generate novel hypotheses for systems biology research is difficult. Traditional Chinese medicine (TCM) is a completely different discipline, and is a complementary knowledge system to modern biomedical(More)
—Traditional Chinese medicine (TCM) is a clinical medical discipline with clinical data as one of the main knowledge sources. The clinical information (e.g. symptoms, diagnoses and herb prescriptions) that is captured, generated and used by TCM physicians has complicated inter or intra relationships between the different elements. Due to the co-occurrence(More)