Clathrin and the multi-subunit adaptor protein complex AP2 are central players in clathrin-mediated endocytosis by which the cell selectively internalizes surface materials. Here, we report the… (More)
More and more novel usage models require the capability of resource sharing among different platforms. To achieve a satisfactory efficiency, we introduce a specific resource sharing technology under… (More)
Lysosomes respond to environmental cues by controlling their own biogenesis, but the underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC)-dependent and… (More)
Phosphatidylinositol 3-phosphate (PtdIns3P) plays a central role in endosome fusion, recycling, sorting, and early-to-late endosome conversion, but the mechanisms that determine how the correct… (More)
Autophagy-dependent clearance of ubiquitinated and aggregated proteins is critical to protein quality control, but the underlying mechanisms are not well understood. Here, we report the essential… (More)
In Fig. 4 F, a duplicate image of the 90-min time point for the rab-7(RNAi);sorf-1 condition was unintentionally shown as the 60-min time point for the rab-7(RNAi);sorf-2 condition. The authors… (More)
Deficits in Schwann cell–mediated remyelination impair functional restoration after nerve damage, contributing to peripheral neuropathies. The mechanisms mediating block of remyelination remain… (More)