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Sulfide is a natural, widely distributed, poisonous substance. Sulfide: quinone oxidoreductase (SQR) is responsible for the initial oxidation of sulfide in mitochondria. To study transcriptional regulation of sqr after sulfide exposure, a 2.6-kb sqr upstream sequence from echiuran worm Urechis unicinctus was cloned by genome walking. Bioinformatics analysis(More)
Insecticide deltamethrin resistance has presented a difficult obstacle for pest control and the resistance development is complex and associated with many genes. To better understand the possible molecular mechanisms involved in DM stress, in this study, cDNA microarray analysis was employed. 448 differentially expressed genes with at least a 2-fold(More)
OBJECTIVE To explore the role of ZNF217 in regulating cell proliferation, migration and invasion in glioma cells. METHDOS A lentivirus-mediated shRNA-ZNF217 vector was infected into glioma U251 cells, and the interference efficiency was examined by Western blotting. MTT assay, flow cytometry, Transwell assay, and Boyden chamber assay were used to analyze(More)
BACKGROUND Sulfide is a well-known environmental toxic substance. Mitochondrial sulfide oxidation is a main mechanism of sulfide detoxification in organisms, and sulfide: quinone oxidoreductase (SQR) is a key enzyme which is involved in transferring electrons from sulfide to ubiquinone and converting sulfide into thiosulfate. Previous studies have revealed(More)
Tyrosyl-tRNA synthetase (TyrRS) is well known for its essential aminoacylation function in protein synthesis. Recently, TyrRS has been shown to translocate to the nucleus and protect against DNA damage due to oxidative stress. However, the mechanism of TyrRS nuclear localization has not yet been determined. Herein, we report that TyrRS becomes highly(More)
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