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Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species*
Background: The molecular mechanisms of endotoxin tolerance remain not well elucidated. Results: IRG1, up-regulated by LPS and during sepsis, can feedback suppress the Toll-like receptor-triggeredExpand
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Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats
In the present study, we examined the mechanisms of hydrogen-rich saline, a reported therapeutic antioxidant, in the treatment of acute spinal cord contusion injury. Male Sprague-Dawley rats wereExpand
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MicroRNAs in the regulation of TLR and RIG-I pathways
The innate immune system recognizes invading pathogens through germline-encoded pattern recognition receptors (PRRs), which elicit innate antimicrobial and inflammatory responses and initiateExpand
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Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysis.
BACKGROUND Emerging evidence has shown that the most common polymorphism (A118G; rs1799971 A>G) in the μ-opioid receptor (OPRM1) gene may influence the response to labor analgesia, but individuallyExpand
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TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism
Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome (MODS) following pulmonary infection. Alveolar macrophages (AM) are at the center of the pathogenesis of theExpand
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Aging‐related Atg5 defect impairs neutrophil extracellular traps formation
Formation of neutrophil extracellular traps (NETs) is an important function of the innate immune system against infections. It has been proven that aging dysregulates immunity and impairs neutrophilExpand
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Hemorrhagic Shock Augments Nlrp3 Inflammasome Activation in the Lung through Impaired Pyrin Induction
Hemorrhagic shock (HS) promotes the development of systemic inflammatory response syndrome and organ injury by activating and priming the innate immune system for an exaggerated inflammatory responseExpand
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Effects of premedication of midazolam or clonidine on perioperative anxiety and pain in children.
The aim of the present study was to compare clinical effects of oral midazolam and clonidine premedication in children. In a prospective randomized double blind trial, 45 children between 2-8 yearsExpand
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Oxytocin is expressed by both intrinsic sensory and secretomotor neurons in the enteric nervous system of guinea pig
Single- and double-immunostaining techniques were used systematically to study the distribution pattern and neurochemical density of oxytocin-immunoreactive (-ir) neurons in the digestive tract ofExpand
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Role of mast cell activation in inducing microglial cells to release neurotrophin
The brain‐derived neurotrophic factor (BDNF) plays a critical role in pain hypersensitivity. BDNF is the ligand of P2X4 receptors (P2X4R) in the microglia. The causative factors involving the P2X4RExpand
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